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Shama Kabekkodu

Also known as: Kabekkodu SP

Manipal School of Life Sciences, Manipal Academy of Higher Education

ORCID iD 0000-0002-4158-3893
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About

Dr. Shama Prasada Kabekkodu’s research has significantly advanced the understanding of cancer genomics, epigenetics, and mitochondrial biology, with a strong emphasis on biomarker discovery and molecular mechanisms in cervical, oral, and breast cancers. His team identified and functionally validated several cancer-associated genes—including *ARHGAP6, DAPK1, DOC2B, HAND2, NKX2-2, NNAT, PCDH10, PROX1, PITX2*, and RAB6C—as diagnostic and prognostic markers for cervical and oral tongue cancer (Tumour Biol. 2017; Virchows Arch. 2017). Notably, they demonstrated DOC2B as a tumor suppressor in cervical cancer, regulating Wnt/β-catenin signaling (Pharmacological Research, 2022) and exocytosis-mediated metastasis (Cell Biology and Toxicology, 2021), with recent work further elucidating the biological functions of extracellular vesicle-associated DOC2B in tumor progression (Scientific Reports, 2025). His group pioneered whole mitochondrial genome sequencing in cervical cancer and congenital cataracts (Mitochondrion, 2014; Mol Vis. 2012), revealing mtDNA mutations’ role in disease pathogenesis. Additionally, they uncovered methylation-regulated miRNAs (Mol Carcinog. 2018; Gynecologic Oncology, 2019) and identified ZNF471 co-methylation as a diagnostic tool (Cell Biology and Toxicology, 2021). Their recent work highlighted the tumor-suppressive role of the chromosome 14 miRNA cluster, epigenetically silenced in cervical cancer (Molecular Oncology, 2024), and demonstrated how the ester derivative palmitoylcarnitine induces lipotoxicity and mitochondrial dysfunction to abrogate cervical cancer cell survival (Cell Communication and Signaling, 2025). These findings are complemented by patented molecular signatures for breast (US Patent WO2011128820A3), colorectal (Indian Patent 347350), and cervical cancers (Indian Patent 472110), underscoring their translational impact. Dr. Kabekkodu’s interdisciplinary approach—integrating bioinformatics, multi-omics, and functional assays provided critical insights into cancer progression, therapy resistance, and precision diagnostics. Dr. Kabekkodu’s research has advanced the understanding of epigenetic dysregulation in cervical cancer and the role of environmental toxins in cancer development. His work bridges basic science and clinical applications, offering new avenues for early detection, prevention, and targeted therapies in cancer.

Employment

  • Manipal School of Life Sciences, Manipal Academy of Higher Education Professor
    2022 - Present

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (165)