Mutsuko Kukimoto-Niino

Employment

• RIKEN Center for Biosystems Dynamics Research
  2018 - Present
• RIKEN Center for Life Science Technologies
  2013 - 2018

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (71)

• Structural basis for membrane-dependent positive feedback regulation of DOCK11 by activated Cdc42
  Proceedings of the National Academy of Sciences 2026 DOI: 10.1073/pnas.2607665123
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• Structural basis for auto-inhibition of the Rac1/Cdc42 guanine nucleotide exchange factor DOCK6 by oligomer formation
  Communications Biology 2026 DOI: 10.1038/s42003-026-10383-w
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• Conformational alteration of DOCK5•ELMO1 signalosome on lipid membrane
  Communications Biology 2025 DOI: 10.1038/s42003-025-09113-5
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• RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state
  Mutsuko Kukimoto‐Niino, Kazushige Katsura, Yoshiko Ishizuka‐Katsura +7 more
  Journal of Biological Chemistry 2024 DOI: 10.1016/j.jbc.2024.107459
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• Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape
  Current Issues in Molecular Biology 2024 DOI: 10.3390/cimb46040194
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• A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer
  npj Precision Oncology 2024 DOI: 10.1038/s41698-024-00542-9
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• RhoG-Binding Domain of Elmo1 Ameliorates Excessive Process Elongation Induced by Autism Spectrum Disorder-Associated Sema5A
  Pathophysiology 2023 DOI: 10.3390/pathophysiology30040040
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• Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor
  Biochemical and Biophysical Research Communications 2023 DOI: 10.1016/j.bbrc.2023.02.054
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• Targeting Ras-binding domain of ELMO1 by computational nanobody design
  Communications Biology 2023 DOI: 10.1038/s42003-023-04657-w
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• Structural Insight into TNIK Inhibition
  International Journal of Molecular Sciences 2022 DOI: 10.3390/ijms232113010
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• Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex
  Mutsuko Kukimoto‐Niino, Kazushige Katsura, Rahul Kaushik +10 more
  Science Advances 2021 DOI: 10.1126/sciadv.abg3147
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• Reduced efficacy of a Src kinase inhibitor in crowded protein solution
  Nature Communications 2021 DOI: 10.1038/s41467-021-24349-5
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• Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells
  Autophagy 2021 DOI: 10.1080/15548627.2021.1911017
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• A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8
  Life Science Alliance 2021 DOI: 10.26508/lsa.202000873
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• Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer
  Nature Communications 2021 DOI: 10.1038/s41467-021-21396-w
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• Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN
  Frontiers in Immunology 2019 DOI: 10.3389/fimmu.2019.01450
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• Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor
  Structure 2019 DOI: 10.1016/j.str.2019.02.001
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• Structural Basis for the Inhibition of Cyclin G‐Associated Kinase by Gefitinib
  ChemistryOpen 2018 DOI: 10.1002/open.201800177
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• Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody-antigen interaction
  Plos One 2018 DOI: 10.1371/journal.pone.0193158
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• Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye
  Science Signaling 2018 DOI: 10.1126/scisignal.aao4874
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