RAJESH KUMAR YADAV
National Institute of Immunology, Amity University, Indian Institute of Chemical Biology CSIR and Jadavpur University, University of Calcutta, All India Institute of Medical Sciences Patna
About
I am a group leader of the Cancer Epigenomics Laboratory (CEL) at the National Institute of Immunology (NII), New Delhi, India. Our research program is to understand how epigenetic mechanisms contribute to cancer pathogenesis, genomic instability, and cancer immunotherapy. We are employing cellular and molecular biology approaches, including genomics, to study the function of histones and chromatin modifiers within an interdisciplinary research program. Our goal is to understand the mechanisms of histone mutations in tumor progression. Furthermore, we propose to enhance the antitumor potential of Chimeric antigen receptor (CAR) T cells by manipulating chromatin modifiers. Over the course of my research career, I was trained primarily as a biochemist, molecular cell biologist, and geneticist. During that period, I learned about proteins and their complexes in various systems, including protozoan parasites and yeast cells. We aim to develop cellular and chemotherapeutic agents for cancer management.
Employment
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National Institute of Immunology Scientist-IV2023 - Present
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Amity University Associate Professor and Ramalingaswami Fellow2022 - 2023
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All India Institute of Medical Sciences Patna Ramalingaswami Re-entry Fellow equivalent to Assistant Professor2019 - 2021
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Adamas University Assistant Professor2018 - 2019
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St. Jude Children's Research Hospital Postdoctoral Research Fellow2011 - 2017
Education
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Indian Institute of Chemical Biology CSIR and Jadavpur University PhD2006 - 2011
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University of Calcutta M.Sc.2002 - 2004
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University of Calcutta B.Sc1999 - 2002
Projects & Funding
Projects & funding information is unavailable.
Publications (21)
- Emerging roles of cancer-associated histone mutations in genomic instabilities Save
- Evaluation of C4b as an adjunct marker in symptomatic RT-PCR negative Covid-19 cases Save
- Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail Save
- Evaluation of Complement Pathway Activation Markers in COVID-19 Patients Save
- Evaluation of Complement Pathway Activation Markers in COVID-19 Patients Save
- Subtelomeric chromatin in the fission yeast s. Pombe Save
- CAR T cell therapy: newer approaches to counter resistance and cost Save
- Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail Save
- Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. Pombe Save
- Histone H3 mutations—a special role for H3.3 in tumorigenesis? Save