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Silviu-Alin Bacanu
Also known as: Silviu-Alin Bacanu
Virginia Commonwealth University, GlaxoSmithKline USA, University of Pittsburgh, West University
Research areas: Biochemistry, Genetics and Molecular Biology · Genetics · Genetic Associations and Epidemiology · Schizophrenia research and treatment · Genetic Mapping and Diversity in Plants and Animals
0000-0002-4364-1583
Employment
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Virginia Commonwealth University Professor2011 - Present
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GlaxoSmithKline USA Principal Biostatistician2005 - 2011
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University of Pittsburgh Research Assistant Professor1999 - 2005
Education
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University of Pittsburgh Ph. D.1993 - 1998
- 1993 - 1995
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West University B.S.1989 - 1993
Projects & Funding
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Using novel eQTL-based methods to find the molecular causes of alcohol dependency National Institute on Alcohol Abuse and Alcoholism2014 - 2016
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Using genetic overlap to dissect the genetic architecture of psychiatric diseases National Institute of Mental Health2014 - 2016
Publications (195)
- Advancing models of PTSD–AUD comorbidity: protocol for a multimethod framework using genetics and ecological momentary assessment Save
- Suicidality phenotypes reflect both shared and distinct genetic factors Save
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling Save
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling Save
- Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries Save
- Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder Save
- Improving the discovery of rare variants associated with alcohol problems by leveraging machine learning phenotype prediction and functional information Save
- Integrative Post-Genome-Wide Association Study Analyses Relevant to Psychiatric Disorders: Imputing Transcriptome and Proteome Signals Save
- Examining the source of increased bipolar disorder and major depressive disorder common risk variation burden in multiplex schizophrenia families Save
- Deep Learning-based Phenotype Imputation on Population-scale Biobank Data Increases Genetic Discoveries Save
- Phenotype integration improves power and preserves specificity in biobank-based genetic studies of MDD Save
- Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects. Save
- Identifying the Common Genetic Basis of Antidepressant Response. Save
- Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Save
- Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach Save
- Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia. Save
- Differences in genetic risk score profiles for drug use disorder, major depression, and ADHD as a function of sex, age at onset, recurrence, mode of ascertainment, and treatment. Save
- Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19. Save
- Investigating the source of increased bipolar and major depressive disorder polygenic risk in multiplex schizophrenia families Save
- The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study. Save