0000-0002-4404-8327 About
Dr. Rajesh Pandey’s tryst with Biological Science started with Graduate degree in Zoology from University of Calcutta, followed by Master’s degree in Zoology, from University of Delhi. During PhD in Biotechnology from CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), he functionally elucidated the regulatory role played by Noncoding RNAs in Stress Response. Subsequently, Rajesh’s stint as Research Scientist at Johns Hopkins University, Maryland, USA and MRC Harwell Institute, Oxfordshire, UK, helped enhance the understanding further with exposure to different diseases and strength of Genomics.
As Principal Scientist and Group leader at CSIR-IGIB, his lab is focussed on INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) to elucidate the hierarchical regulation of factors modulating Disease severity sub-phenotypes and Clinical outcome.
• Genetic uniqueness of pathogens vis-a-vis pathogenicity and symptom severity.
• Role of host protein coding genes towards modulating pathogen's pathogenicity.
• Role of co-infections in delineating pathogen outcome.
• Role of non-coding RNA in modulating pathogen response.
• Cross-talk b/w Cellular heterogeneity (Single Cell Genomics) and effective Immune response.
The pathogen and host response findings have been published in 77 research articles in journals inclusive of Nature, Science, Lancet Infectious diseases, Nature Communications, Cell Reports, Genome Biology, Frontiers in Microbiology, Clinical & Translational Medicine, Microbiology Spectrum and Microbiological Research.
Rajesh has academic interest towards writing Books and book chapters elucidating aspects of host-pathogen Interactome. His 1st Book, RNA-based Regulation in Human Health and Disease, published by Elsevier, is having high global readership. Presently, his 2nd Book, Genomic Surveillance and Pandemic Preparedness, to be published by Elsevier is underway.
Employment
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CSIR Institute of Genomics & Integrative Biology Principal Scientist2020 - 2033
Education
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CSIR Institute of Genomics & Integrative Biology PhD2007 - 2011
Projects & Funding
Projects & funding information is unavailable.
Publications (35)
- Intracellular microbial shifts during COVID-19 infection and longitudinal recovery revealed by single-cell RNA sequencing Save
- Comparative GWAS using global and Indian Reference Panels reveals non-coding drivers of COVID-19 severity and mortality Save
- Transcriptional landscapes of dengue patients reveal associations between HERV activity and disease severity Save
- Protocol for investigating intracellular microbial diversity using single-cell RNA-seq in immune cells of SARS-CoV-2-positive and recovered patients Save
- Phloretin-induced modulation in gut microbiome, mitigates colonic inflammation and alleviates colitis-associated colorectal cancer in mice Save
- Genomic insights into bacteriophages: a new frontier in AMR detection and phage therapy Save
- SARS-CoV-2 Alchemy: Understanding the dynamics of age, vaccination, and geography in the evolution of SARS-CoV-2 in India Save
- Suboptimal dengue genome leverages non-canonical translation mechanisms Save
- Inter-host diversity associated with age, sex, and menstrual cycle modulates clinical manifestations in DENV-2 patients Save
- Non-canonical Metatranscriptomic analysis of COVID-19 and Dengue reveals an expanded microbial and AMR landscape in COVID-19 mortality patients Save