Ana Rita Pedrosa
Queen Mary University of London, Faculdade de Medicina Veterinaria, Universidade de Lisboa
About
I am a CRUK RadNET City of London post-doctoral career development fellow working on a collaborative project between Hodivala-Dilke’s lab at the BCI and the Sahai’s lab at the Crick Institute in London, UK. I did my PhD in Portugal in the lab of Prof. Antonio Duarte, investigating the role of vascular endothelial-cell Jagged1 in physiological and tumour angiogenesis (Pedrosa et al., ATVB, 2015, Pedrosa et al., Oncotarget, 2015, Pedrosa et al., Prostate, 2016 and Pedrosa et al., Methods Mol Biol. 2018). I then moved to the UK in 2016 for postdoctoral studies in the lab of Prof. Hodivala-Dilke at the BCI to continue investigating how tumour vasculature shapes tumour growth and metastasis, thorough focal adhesion kinase signalling (Pedrosa et al., Cancer Res., 2019 and Newport and Pedrosa, et al., JPath., 2022). My most recent work is focusing on understanding how cancer treatments modulate both tumour and pre-metastatic lung niche vasculature derived angiocrine (paracrine and juxtracrine) signals and their crosstalk with the immune system, thus shaping therapeutic responses and metastasis formation, respectively. I am currently starting my final fellow year and looking to transition soon to an independent position where I intend to focus on exploiting immunomodulatory roles of vascular endothelial cells for devising new combinatorial therapeutic approaches for cancer.
Employment
-
Queen Mary University of London CRUK RadNET post-doctoral fellow2021 - 2026
-
Queen Mary University of London Post-doc2016 - 2020
Education
-
Faculdade de Medicina Veterinaria, Universidade de Lisboa Integrated Masters in Veterinary Medicine2002 - 2008
Projects & Funding
Projects & funding information is unavailable.
Publications (15)
- The Angiocrine Niche in Cancer Therapy Responses: The Role of Vascular Endothelial Cells in Immunomodulation Save
- The Angiocrine Niche in Cancer Therapy Responses: The Role of Vascular Endothelial Cells in Immunomodulation Save
- Development and characterisation of improved unifocal primary mouse lung cancer models with metastatic potential Save
- Effects of senescence on the tumour microenvironment and response to therapy Save
- Immune Mechanisms of Resistance to Cediranib in Ovarian Cancer Save
- Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth Save
- Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression Save
- Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth Save
- “Splitting the matrix”: intussusceptive angiogenesis meets <scp>MT</scp> 1- <scp>MMP</scp> Save
- Tumor angiogenesis is differentially regulated by phosphorylation of endothelial cell focal adhesion kinase tyrosines-397 and -861 Save