AK
Abhay Kotecha
St. Jude Children's Research Hospital, University of Oxford, Oxford Brookes University, Thermo Fisher Scientific (Netherlands)
Research areas: Biochemistry, Genetics and Molecular Biology · Structural Biology · Advanced Electron Microscopy Techniques and Applications · Enzyme Structure and Function · Protein Structure and Dynamics
0000-0002-4480-5439
Employment
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St. Jude Children's Research Hospital Principal Scientist and Sr. Director of Technologies for Cryo-EM and Cryo-ET2024 - Present
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Thermo Fisher Scientific (Netherlands) Group Leader2018 - 2024
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University of Oxford Post-doctoral fellow in virus structural biology2013 - Present
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University of Oxford DPhil in Structure Biology2008 - 2014
Education
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University of Oxford DPhil in Structural Biology2008 - 2013
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Oxford Brookes University BSc. Hons. Cell and Molecular Biology2004 - 2008
Projects & Funding
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Structure and Dynamics of Picornavirus Capsids to Inform Vaccine Design Oxford University Press2008 - 2012
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Structural and functional characterisation of ATAD2, a novel human chromatin remodelling protein containing bromo and AAA+ ATPase domains. Wellcome Trust2008 - 2012
Publications (99)
- Shaping cryogenic 3D volume imaging by pFIB ion species and milling voltage Save
- Structural and functional mapping of protective human monoclonal antibodies against enterovirus A71 Save
- Structural basis of signal peptide recognition by the signal peptidase complex Save
- In-cell architecture of the mitochondrial respiratory chain Save
- TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network Save
- Conformational diversity in class C GPCR positive allosteric modulation Save
- In-cell architecture of the mitochondrial respiratory chain Save
- CryoDRGN-ET: deep reconstructing generative networks for visualizing dynamic biomolecules inside cells Save
- Cryo-EM structure of SRP68/72 reveals an extended dimerization domain with RNA-binding activity Save
- Disease-specific tau filaments assemble via polymorphic intermediates Save
- Functional and structural insights into activation of TRPV2 by weak acids Save
- High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design Save
- Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes Save
- Sub-3 Å resolution protein structure determination by single-particle cryo-EM at 100 keV Save
- Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants Save
- A Facility View - Maximizing Biological Discovery in Microscopy Save
- Conformational diversity in class C GPCR positive allosteric modulation Save
- Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration Save
- Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer’s disease and corticobasal degeneration Save
- Deep reconstructing generative networks for visualizing dynamic biomolecules inside cells Save