LC
Lu Chen
Also known as: 陈路
Fox Chase Cancer Center, Stanford University, University of Kansas Medical Center, Stowers Institute for Medical Research
Research areas: Medicine · Oncology · interferon and immune responses · Lung Cancer Research Studies · Cancer Immunotherapy and Biomarkers
0000-0002-4571-7975
Employment
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Fox Chase Cancer Center Assistant Professor2021 - Present
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Stanford University Instructor2020 - 2021
Education
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Stanford University School of Medicine Postdoctoral Fellow2013 - Present
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Stanford University School of Medicine Postdoctoral Fellow2013 - Present
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Stanford University School of Medicine Postdoctoral Fellow2013 - Present
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University of Kansas Medical Center PhD student2007 - 2013
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Stowers Institute for Medical Research phD student2007 - 2013
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Institute of Biophysics Chinese Academy of Sciences undergraduate thesis research2005 - 2007
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Wuhan University undergraduate2002 - 2006
Projects & Funding
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Supplement award to "Telomerase RNP Prisonbreaks from Phase-Separated Nuclear Body" National Institute of General Medical Sciences2024 - 2025
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Telomerase RNP Prisonbreaks from Phase-Separated Nuclear Body National Institute of General Medical Sciences2023 - 2028
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How a noncoding driver mutation drives cancer immortality Stanford Cancer Institute2018 - 2019
Publications (24)
- Preparation of Extracellular Matrices and Cell/Matrix Functional Units Produced by Cultured and Primary Fibroblasts Save
- Intranucleolar Invasion of Cajal Body Remnants Suppresses Ribosomal Biogenesis in cis and Telomerase Functions in trans Save
- NFIB::PHACTR2, a novel atypical fusion gene identified in adenoid cystic carcinoma of the palate Save
- Biogenesis and Regulation of Telomerase during Development and Cancer. Save
- Clonal inactivation of TERT impairs stem cell competition Save
- Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer Save
- The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats Save
- TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration. Save
- The S‐adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening Save
- Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE Save
- Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus. Save
- A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma Save
- Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation. Save
- Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease. Save
- An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1. Save
- Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury. Save
- Biochemical assays for analyzing activities of ATP-dependent chromatin remodeling enzymes Save
- Generation and purification of human INO80 chromatin remodeling complexes and subcomplexes Save
- Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif Save
- Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatinremodeling complex Save