Divya Rai

About

Dr. Divya Rai is a Ph.D. graduate in Endocrinology from the CSIR-Central Drug Research Institute (CDRI), Lucknow. Their doctoral research focused on investigating the role of small molecules and cross-kingdom miRNA in bone anabolism. Notable achievements include identifying galloyl conjugates of flavanones as potent BMP2 secretagogues, with demonstrated efficacy in fracture healing and glucocorticoid-induced osteoporosis. Dr. Divya Rai also explored the regulatory effects of food-derived miRNAs, isolating a miRNA from Glycine max (soybean) that enhances bone formation by targeting SOSTDC1.

With expertise in research methodologies, data analysis, and scientific writing, Dr. Divya Rai has authored multiple first-author publications and contributed to collaborative research efforts in the field of bone biology. Committed to advancing the therapeutic potential of bone anabolics, Dr. Divya Rai is dedicated to bridging basic science and clinical applications for improved human health outcomes.

Employment

• KnowledgeWorks Global Ltd Subject Matter Expert
  2024 - Present
• Central Drug Research Institute Project Associate II
  2024 - 2024
• Central Drug Research Institute Senior Research Fellow
  2020 - 2024
• Central Drug Research Institute Junior Research Fellow
  2018 - 2020

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (11)

• miR4352b a cross-species modulator of SOSTDC1, targets dual pathway to regulate bone health and fracture healing.
  Biochimica et biophysica acta. Molecular basis of disease 2024 DOI: 10.1016/j.bbadis.2024.167514
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• Withaferin A Ameliorated the Bone Marrow Fat Content in Obese Male Mice by Favoring Osteogenesis in Bone Marrow Mesenchymal Stem Cells and Preserving the Bone Mineral Density.
  ACS pharmacology & translational science 2024 DOI: 10.1021/acsptsci.3c00356
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• A glucuronated flavone TMMG spatially targets chondrocytes to alleviate cartilage degeneration through negative regulation of IL-1β
  Biomedicine & Pharmacotherapy 2023 DOI: 10.1016/j.biopha.2023.114809
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• Design, synthesis and biological evaluation of new quinazolinone-benzopyran-indole hybrid compounds promoting osteogenesis through BMP2 upregulation
  European Journal of Medicinal Chemistry 2022 DOI: 10.1016/j.ejmech.2022.114813
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• Nanoparticles of naturally occurring PPAR-γ inhibitor betulinic acid ameliorates bone marrow adiposity and pathological bone loss in ovariectomized rats via Wnt/β-catenin pathway.
  Life sciences 2022 DOI: 10.1016/j.lfs.2022.121020
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• A novel BMP2 secretagogue ameliorates glucocorticoid induced oxidative stress in osteoblasts by activating NRF2 dependent survival while promoting Wnt/β-catenin mediated osteogenesis.
  Free radical biology & medicine 2022 DOI: 10.1016/j.freeradbiomed.2022.08.007
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• Benzofuran pyran hybrid prevents glucocorticoid induced osteoporosis in mice via modulation of canonical Wnt/β-catenin signaling
  Apoptosis 2022 DOI: 10.1007/s10495-021-01702-z
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• Caviunin glycoside (CAFG) from Dalbergia sissoo attenuates osteoarthritis by modulating chondrogenic and matrix regulating proteins
  Journal of Ethnopharmacology 2022 DOI: 10.1016/j.jep.2021.114315
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• Synthesis and Evaluation of Galloyl Conjugates of Flavanones as BMP-2 Upregulators with Promising Bone Anabolic and Fracture Healing Properties.
  Journal of medicinal chemistry 2021 DOI: 10.1021/acs.jmedchem.1c00112
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• Benzofuran pyran compound rescues rat and human osteoblast from lipotoxic effect of palmitate by inhibiting lipid biosynthesis and promoting stabilization of RUNX2
  Toxicology in Vitro 2020 DOI: 10.1016/j.tiv.2020.104872
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