Dr. Manish Singh Sansi
National Dairy Research Institute, Central University of Rajasthan, University of Rajasthan
0000-0002-4723-4803
About
My research centers on the functional characterization, valorization, and formulation of food-derived proteins and peptides for health-promoting applications. Expertise bridges food chemistry, protein & peptide, and nanobiotechnology, focusing on how structural transformations of proteins during processing and digestion influence nutrient bioavailability and bioactive peptide generation. I have experinced to developed in vitro digestion models (INFOGEST) and applied advanced analytical and spectroscopic tools such as FTIR, UV, NIR, XRD, SEM, DLS, and rheology to elucidate protein structure–function relationships at molecular and macroscopic levels.
I have extensive experience in proteomics, peptidomics & metabolomics, using LC-MS/MS, QTOF-MS, and HR-LC/MS platforms coupled with bioinformatics tools (MaxQuant, Perseus, STRING, Cytoscape) to identify and characterize bioactive peptides/ metabolites with antidiabetic, antiobesity, and antimicrobial properties. His work integrates in silico prediction and molecular docking to assess peptide–target interactions, complemented by metabolomics and cell-based assays (HT-29, C57BL/6J mice models) for functional validation.
I have also designed nanostructured food systems including whey protein nanoparticles, cellulose nanofibers, and peptide-based nanocomposites to enhance stability, controlled release, and bioavailability of functional ingredients. My research promotes the sustainable utilization of dairy side streams, transforming industrial by-products into high-value bioactive compounds for next-generation therapeutic and functional food formulations.
Employment
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National Dairy Research Institute Senior Research Fellow2021 - 2024
Education
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Central University of Rajasthan MS2013 - 2016
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University of Rajasthan BS2010 - 2013
Projects & Funding
Projects & funding information is unavailable.
Publications (18)
- Bikaneri Camel Milk-Derived Low-Molecular-Weight Peptides as a Novel Therapeutic Approach for Diabetes Save
- Mass Spectrometry-Guided Library Preparation of Peptides as Metabolic Enzyme Natural Inhibitors for the Management of Obesity and Diabetes Save
- Valorization of paneer waste whey through fermentation with Pediococcus pentosaceus NCDC 273 insights from intracellular metabolomics by GC-MS Save
- Genome based analysis of Antibacterial Biosynthetic Clusters in Lactiplantibacillus plantarum C6 and Exploration of their Natural Small Molecules as anti-biofilm in Methicillin-Resistant Staphylococcus aureus Save
- Designing Functional Dairy Food Products: Peptide-Fortification Approaches to Improve Safety, Quality, and Consumer Acceptance Save
- Draft genome sequence of Lactobacillus rhamnosus C25 , isolated from an Indian dairy cheese Save
- “Decoding Mobile Genetic Elements, Virulence Factors, and Antibiotic Resistance Genes Driving Biofilm Formation in MRSA via Network Analysis” Save
- Phenotypic and molecular characterization of clinically isolated antibiotics-resistant S. aureus (MRSA), E. coli (ESBL) and Acinetobacter 1379 bacterial strains Save
- In vitro biosafety and bioactivity assessment of the goat milk protein derived hydrolysates peptides Save
- Effect of metal oxide nanoparticles on biochemical pathways in plants Save