Priyank Kumar
Western University of Health Sciences, Marshall B. Ketchum University, St Johns University, Rajiv Academy for Pharmacy
Research areas: Medicine · Microbiology · Antibiotic Resistance in Bacteria · Drug Transport and Resistance Mechanisms · Pharmacogenetics and Drug Metabolism
About
My Lab investigates critical molecular mechanisms underlying microbial pathogenicity and drug resistance, particularly in contexts where veterinary and human patients face environmental toxins and substances of abuse. Our research employs innovative approaches to understand how these external factors influence microbial behavior and drug response profiles.
Our primary focus is deciphering the complex interactions between microorganisms and host systems under stressed conditions. We examine how exposure to environmental toxins and substances of abuse alters microbial virulence factors and antimicrobial resistance patterns. This research is crucial for understanding the impact of modern environmental and lifestyle factors on infectious disease progression and treatment outcomes.
A key aspect of our work involves developing personalized therapeutic strategies based on specific microbial profiles. By characterizing how different microbes respond to various stressors and antimicrobial agents, we aim to optimize treatment protocols that consider both the pathogen's characteristics and the patient's exposure history. This approach enables us to design more effective, targeted interventions for both veterinary and human medicine.
Our goal is to advance the field of precision antimicrobial therapy by understanding the fundamental relationships between environmental factors, microbial adaptation, and treatment efficacy. This research has significant implications for addressing the growing challenges of antimicrobial resistance in both veterinary and human medicine
Employment
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Western University of Health Sciences Associate Professor2023 - Present
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Marshall B. Ketchum University Associate Professor2018 - Present
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Touro College Assistant Professor2014 - 2018
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St Johns University Teaching Fellow2008 - Present
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St Johns University Teaching Assistant2005 - 2008
Education
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St Johns University Phd2008 - 2014
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St Johns University M.S.2005 - 2008
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Rajiv Academy for Pharmacy B. Pharma1999 - 2003
Projects & Funding
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Teaching Fellowship St Johns University
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Teaching Assistantship St Johns University
Publications (19)
- Multifaceted Antibiotic Resistance in Diabetic Foot Infections: A Systematic Review Save
- Mycobacterium marinum Immune Evasion in Zebrafish Save
- Structural and biological aspects of natural bridged macrobicyclic peptides from marine resources Save
- Emergence of antimicrobial resistance in hospitals Save
- Physical Methods for systemic delivery Save
- Misc. medical devices and technologies Save
- Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and in vivo studies Save
- A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDRin vitroandin vivo Save
- P-gp Inhibitory Activity from Marine Sponges, Tunicates and Algae Save
- Exposing the Origins of the Ebola Outbreak: Urging for a Shift in Response from Reactive to Proactive Save
- Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo. Save
- Ponatinib enhances anticancer drug sensitivity in MRP7-overexpressing cells Save
- Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1 Save
- Reversal of MRP7 (ABCC10)-mediated multidrug resistance by tariquidar. Save
- Role of ABC transporters in cancer chemotherapy. Save
- Autophagy and transporter-based multi-drug resistance. Save
- Hydromorphone efficacy and treatment protocol impact on tolerance and mu-opioid receptor regulation. Save
- Mu-opioid receptor up-regulation and functional supersensitivity are independent of antagonist efficacy. Save
- Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of mu-opioid receptors and dynamin-2. Save