Sriram Sridharan

Employment

• BRIC-National Institute of Biomedical Genomics Ramalingaswami Fellow
  2025 - Present
• National University of Singapore Special Fellow
  2022 - 2025
• National Institutes of Health Postdoctoral Fellow
  2015 - 2020

Education

• Texas A&M University Doctor of Philosophy
  2008 - 2015
• Indian Institute of Technology Roorkee Master of Technology
  2006 - 2008

Projects & Funding

Projects & funding information is unavailable.

Publications (9)

• Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation
  EMBO Molecular Medicine 2023 DOI: 10.15252/emmm.202317973
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• Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability
  Nature Cell Biology 2023 DOI: 10.1038/s41556-023-01167-z
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• Clinical relevance of PD-1 positive CD8 T-cells in gastric cancer
  Gastric Cancer 2023 DOI: 10.1007/s10120-023-01364-7
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• Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis.
  Cell reports 2022 DOI: 10.1016/j.celrep.2022.110871
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• Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
  Nature 2020 DOI: 10.1038/s41586-020-2769-8
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• ATR inhibition potentiates ionizing radiation-induced interferon response via cytosolic nucleic acid-sensing pathways.
  The EMBO journal 2020 DOI: 10.15252/embj.2019104036
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• A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia.
  JCI insight 2019 DOI: 10.1172/jci.insight.131434
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• Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.
  Cell 2018 DOI: 10.1016/j.cell.2018.07.011
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• DNA Breaks and End Resection Measured Genome-wide by End Sequencing.
  Molecular cell 2016 DOI: 10.1016/j.molcel.2016.06.034
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