Jijo Lukose

About

Present research work is focused on exploring Raman Tweezers for evaluating the various disorders related to blood components.My expertise include, design and development of biosensors, based on optical techniques such as surface plasmon resonance (SPR), surface enhanced Raman spectroscopy (SERS), for applications including biomarker detection, pathogen detection etc. In addition, real time monitoring of antigen-antibody interaction is also being investigated. Self-assembled monolayer (SAM) formation on metal surfaces (silver, gold) and surface functionalization using biomolecules are also areas of interest. Contact angle measurements, Raman spectroscopy are characterization techniques used to confirm the presence of immobilized biomolecules on the metal surfaces. The approach followed predominantly considers the sensitivity, cost effectiveness of the developed system, in order to compete with commercially available ones. Also includes exploring the spectroscopic techniques for breath analysis.

Employment

• Manipal Academy of Higher Education Assistant Professor
  2019 - Present
• Manipal University Postdoctoral Fellow
  2017 - Present

Education

• Manipal University Ph.D
  2011 - 2016
• Cochin University of Science and Technology Integrated Masters in Photonics
  2006 - 2011

Projects & Funding

Projects & funding information is unavailable.

Publications (12)

• Laser induced fluorescence of cervical tissues: an in-vitro study for the diagnosis of cervical cancer from the cervicitis
  Journal of Optics 2022 DOI: 10.1088/2040-8986/ac59e2
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• Probing Nanoparticle–Cell Interaction Using Micro-Raman Spectroscopy: Silver and Gold Nanoparticle-Induced Stress Effects on Optically Trapped Live Red Blood Cells
  ACS Omega 2020 DOI: 10.1021/acsomega.9b02988
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• Red blood cells under varying extracellular tonicity conditions: an optical tweezers combined with micro-Raman study
  Biomedical Physics & Engineering Express 2020 DOI: 10.1088/2057-1976/ab6e1a
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• Human red blood cell behaviour in hydroxyethyl starch: probed by single cell spectroscopy
  RSC Advances 2020 DOI: 10.1039/D0RA05842D
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• Optical tweezers combined with micro‐Raman investigation of alcohol‐induced changes on single, live red blood cells in blood plasma
  Journal of Raman Spectroscopy 2019 DOI: 10.1002/jrs.5638
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• Laser Raman tweezer spectroscopy to explore the bisphenol A-induced changes in human erythrocytes
  RSC Advances 2019 DOI: 10.1039/C9RA01840A
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• Normal saline-induced deoxygenation of red blood cells probed by optical tweezers combined with the micro-Raman technique
  RSC Advances 2019 DOI: 10.1039/C8RA10061F
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• Real-time and rapid detection of Salmonella Typhimurium using an inexpensive lab-built surface plasmon resonance setup
  Laser Physics Letters 2018
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• Real Time Monitoring of Biomolecular Interactions Using Lab-Built Surface Plasmon Resonance (SPR) Instrument
  Advanced Science Letters 2017
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• Smaller to larger biomolecule detection using a lab-built surface plasmon resonance based instrument
  Laser Physics 2016
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