Dhiraj Dhotre

About

I am a Scientist at the National Centre for Cell Science (NCCS), Pune, with extensive experience in the fields of microbial genomics, metagenomics, and bioinformatics. My research is driven by a deep interest in the human microbiome, specifically the characterization of the Indian microbial signature and its implications for health and disease.

My work encompasses both fundamental and applied research. I have been actively involved in projects ranging from the study of Indian Human Microbiome Initiative, gut-brain axis interactions, celiac disease and oxalate-metabolizing bacteria to the development of precision probiotics tailored to specific Indian gut enterotypes. As a lead researcher on the "Biofoundry" project, I am also committed to bridging academia and industry to scale up bioprocesses for the production of industrially relevant molecules.

My career trajectory has been defined by a multidisciplinary approach, utilizing advanced computational tools to analyze complex multi-meta-omic datasets. I am passionate about understanding the biological mechanisms of human microbiome in public health. Beyond my research at NCCS, I am actively engaged in the global scientific community, participating in international symposia and fostering collaborative efforts to translate microbial discoveries into practical health solutions.

Employment

• National Centre for Cell Science Scientist
  2021 - Present
• Reliance Life Sciences Pvt Ltd Senior Research Scientist
  2019 - 2021
• National Centre For Cell Science Scientist
  2009 - Present

Education

• University of Pune PhD
  2005 - 2014

Projects & Funding

Projects & funding information is unavailable.

Publications (34)

• Harnessing gut microbiome enzymes: Segatella copri and Stenotrophomonas maltophilia prolyl peptidases degrade gliadin peptides and improve epithelial barrier function in a celiac disease model
  Microbiology Spectrum 2026 DOI: 10.1128/spectrum.03214-25
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• Evaluation of extraction solvents for untargeted metabolomics in characterizing Antarctic cryoconite hole dissolved organic matter
  Analytica Chimica Acta 2026 DOI: 10.1016/j.aca.2026.345648
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• Assessment of seasonal variations in antibiotic resistance genes and microbial communities in sewage treatment plants for public health monitoring
  Environmental Pollution 2025 DOI: 10.1016/j.envpol.2025.126367
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• Dataset of ileum bacterial diversity in mice after heart failure due to pressure overload
  Data in Brief 2022 DOI: 10.1016/j.dib.2022.108498
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• False-positive detection of Group B Streptococcus (GBS) in chromogenic media (Strep B Carrot Broth) due to presence of Enterococcus faecalis in High Vaginal swabs
  Journal of Medical Microbiology 2022 DOI: 10.1099/jmm.0.001577
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• False-positive detection of Group B Streptococcus (GBS) in chromogenic media due to presence of Enterococcus faecalis in High Vaginal Swabs
  2021 DOI: 10.1101/2021.12.17.21267936
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• Nitrincola tapanii sp. nov., a novel alkaliphilic bacterium from An Indian Soda Lake
  International Journal of Systematic and Evolutionary Microbiology 2020 DOI: 10.1099/ijsem.0.003883
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• Mining the Core Gut Microbiome from a Sample Indian Population
  Indian Journal of Microbiology 2019 DOI: 10.1007/s12088-018-0742-0
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• Comparison of Small Gut and Whole Gut Microbiota of First-Degree Relatives with Adult Celiac Disease Patients and Controls
  Frontiers in Microbiology 2019 DOI: 10.3389/fmicb.2019.00164
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• Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains
  BMC genomics 2018 DOI: 10.1186/s12864-018-5043-9
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