Indulekha Pillai
Also known as: Indu Pillai, Indulekha CL, Indulekha Pillai
Amrita Vishwa Vidyapeetham, Cedars-Sinai Medical Center, University of California Los Angeles, University of North Carolina at Chapel Hill, Duke University, Rajiv Gandhi Centre for Biotechnology
0000-0002-5038-6031
About
Currently I am working on the cellular and molecular mechanisms of cardiac calcification with a goal to find therapeutic targets to prevent deposition of calcium in cardiovascular system. Calcification is known to occur through an active bone forming mechanism, however little is known about the cells contributing this process in an adult heart. Using murine models of calcification and genetically labelled transgenic mice, I am delineating the potential progenitors contributing to this process and mechanisms driving these progenitors to adopt an osteoblast (calcium forming cell) fate.
Employment
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Amrita Vishwa Vidyapeetham Assistant professor2016 - Present
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Cedars-Sinai Medical Center2016 - 2016
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Duke University Associate in Research2010 - 2011
Education
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University of California Los Angeles post doctoral fellowship2013 - 2016
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University of North Carolina at Chapel Hill post doctoral fellowship2011 - 2013
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Rajiv Gandhi Centre for Biotechnology PhD2005 - 2011
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University of Kerala Masters in Biotechnology2002 - 2004
Projects & Funding
Projects & funding information is unavailable.
Publications (11)
- Cell autonomous TLR4 signaling modulates TGF-β induced activation of human cardiac fibroblasts Save
- Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification Save
- Mesenchymal-endothelial transition contributes to cardiac neovascularization Save
- Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors Save
- Hes-1 regulates the excitatory fate of neural progenitors through modulation of Tlx3 (HOX11L2) expression Save
- ATF2 maintains a subset of neural progenitors through CBF1/Notch independent Hes-1 expression and synergistically activates the expression of Hes-1 in Notch-dependent neural progenitors Save
- Neuronal vs. Glial Fate of Embryonic Stem Cell-Derived Neural Progenitors (ES-NPs) is Determined by FGF2/EGF During Proliferation Save
- Seizure induces activation of multiple subtypes of neural progenitors and growth factors in hippocampus with neuronal maturation confined to dentate gyrus Save
- A subset of neural progenitors is maintained by ATF-2 mediated non-canonical activation of Hes-1 expression Save
- Hes-1 acts as transcriptional repressor of Tlx3, a selector gene in excitatory over inhibitory neural fate determination Save