Deepak Parashar
Medical College of Wisconsin, National Institute of Immunology, All India Institute of Medical Sciences
Research areas: Medicine · Oncology · Ovarian cancer diagnosis and treatment · Immunotherapy and Immune Responses · Cancer Cells and Metastasis
0000-0002-5062-8950
About
Cancer immunotherapy has an edge over other classical treatment modalities in that it is less prone than conventional drugs to severe side effects. Early detection is the most important aspect of clinical cancer research because it directly improves the efficacy of treatment interventions and survival rate. We are focused on the characterization of novel cancer testis antigens in different malignancies. Cancer-testis (CT) antigens have been indicated as a potential targets for antigen specific immunotherapy because they are not found in somatic tissues except testes but are highly expressed by various malignancies and often trigger humoral immune responses in cancer patients. Because of their expression in immune- privileged site i.e. testis, these CT antigens also show spontaneous immune response in cancer patients. In our lab, I am involved in characterization and expression of novel CT antigens: SPAG9 and AKAP4 and HSP70-2 in various cancer e.g. cervical cancer, ovarian cancer, breast cancer, bladder cancer, colorectal cancer etc. I am also exploring the involvement of key tumor specific molecules in the complex cancer signaling networks. Although the association of these molecules in cellular proliferation, migration and invasion has been established but the precise mechanism which is involved is still unknown. Therefore I am trying to find out and understand the underlying molecular mechanisms involved in tumorigenic properties and behaviors of cancer cells.
Employment
-
Medical College of Wisconsin Assistant Professor2022 - Present
-
Medical College of Wisconsin Research Scientist-I2021 - 2022
-
Medical College of Wisconsin Post Doctorate Fellow2016 - 2021
-
National Institute of Immunology Senior Research Fellow2011 - 2016
-
All India Institute of Medical Sciences Research Assistatnt2008 - 2016
-
All India Institute of Medical Sciences Junior Research Fellow2008 - 2009
Education
-
National Institute of Immunology Ph.D. Biotechnology2011 - 2016
Projects & Funding
Projects & funding information is unavailable.
Publications (49)
- KRAS Mutations in Cancer: Understanding Signaling Pathways to Immune Regulation and the Potential of Immunotherapy Save
- Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and Diagnosis Save
- Extracellular Vesicles in Triple–Negative Breast Cancer: Immune Regulation, Biomarkers, and Immunotherapeutic Potential Save
- Beyond Macromolecules: Extracellular Vesicles as Regulators of Inflammatory Diseases Save
- Emerging Roles and Potential Applications of Non-Coding RNAs in Cervical Cancer Save
- Correction: Parashar et al. Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance. Cancers 2022, 14, 958 Save
- Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance Save
- ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis Save
- Whole-genome shotgun sequence of Halomonas sp. Strain SBS 10, isolated from a hypersaline lake in India Save
- scFv6.C4 DNA vaccine with fragment C of tetanus toxin increases protective immunity against CEA-expressing tumor Save
- Betaine accumulation suppresses the de-novo synthesis of ectoine at a low osmotic concentration in Halomonas sp SBS 10, a bacterium with broad salinity tolerance Save
- miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer Save
- ERBB signaling in CTCs of ovarian cancer and glioblastoma Save
- A novel cancer testis antigen target A-kinase anchor protein (AKAP4) for the early diagnosis and immunotherapy of colon cancer Save
- A novel cancer testis antigen target a-kinase anchor protein (AKAP4) for the early diagnosis and immunotherapy of colon cancer Save
- Heat shock protein 70--2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth Save
- Heat shock protein 70-2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth Save
- Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells Save
- Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells Save
- Sperm-associated antigen 9 (SPAG9), a putative target for early detection and targeted therapy of breast cancer Save