Gundappa Saha
University of Pennsylvania, Indian Institute of Technology Guwahati, Anna University, Chennai, Maulana Abul Kalam Azad University of Technology, West Bengal
Research areas: Medicine · Public Health, Environmental and Occupational Health · Research on Leishmaniasis Studies · Trypanosoma species research and implications · Inflammasome and immune disorders
About
Dr. Gundappa Saha is an immunologist with more than ten years of research experience focused on immune regulation, inflammation, and host–pathogen interactions. His research program is centered on understanding how immune dysfunction contributes to chronic inflammatory and infectious diseases, with an emphasis on uncovering fundamental mechanisms that can be therapeutically targeted. Currently he is working as a “Research Associate” in the University of Pennsylvania, USA.
Dr. Saha earned his PhD in January 2020 from the Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, India where he was awarded the prestigious Prime Minister’s Fellowship for Doctoral Research by the Department of Science and Technology, Government of India. His doctoral work, conducted in collaboration with Cadila Pharmaceuticals Limited, elucidated novel immunosuppressive mechanisms used by Leishmania donovani to evade host inflammatory immune responses during visceral leishmaniasis, highlighting his ability to perform translational and industry-linked research.
Since completing his PhD, Dr. Saha has expanded his expertise into broader areas of immunology and inflammation, integrating in vivo disease models with immune phenotyping and molecular analyses in the University of Pennsylvania as a "Post-Doctoral Researcher". He has contributed to multidisciplinary, high-impact collaborative studies and is a co-author on two publications in Cell, reflecting his ability to engage in rigorous, conceptually driven research at the highest level. He has published more than ten peer-reviewed research articles, with additional manuscripts currently under revision.
Dr. Saha has received multiple national and international research honors, including international travel awards, best young investigator awards, and best poster awards. He has qualified competitive national examinations such as DBT-JRF, GATE, and DBT-CEEB, underscoring his strong academic foundation. His interdisciplinary training, spanning pharmaceutical sciences, biotechnology, and immunology, positions him well to pursue innovative, cross-cutting research questions.
Looking ahead, Dr. Saha aims to establish an independent research program that addresses unanswered and emerging questions in immunity and inflammation, with a focus on translating mechanistic insights into strategies for disease intervention. His long-term goal is to bridge basic immunology with disease biology to advance therapeutic innovation and improve human health outcomes.
Personal Strength: His personal strength is flexibility and versatility to do multi-tasking. Apart from professional qualifications, he is a person who likes to take active participation in sports and cultural activities. He is a person with strong opinion and mindset and gets along with everybody very effortlessly. Apart from research, he is a photographer by passion and likes to travel with his camera and gears. He likes to read books occasionally (mainly autobiographies and biographies). Music is his all-time favorite and likes to play guitar sometimes.
Employment
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University of Pennsylvania Research Associate2025 - Present
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University of Pennsylvania Post Doctoral Researcher2020 - 2025
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Indian Institute of Technology Guwahati Senior Research Fellow2014 - 2014
Education
- 2014 - 2020
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Anna University, Chennai M.Tech2012 - 2014
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West Bengal University of Technology B. Pharm2008 - 2012
Projects & Funding
Projects & funding information is unavailable.
Publications (16)
- IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss Save
- Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss Save
- Gene Alterations Induced by Glutamine (Q) Encoding CAG Repeats Associated with Neurodegeneration Save
- In Vitro Assay for the Assessment of Oxygen Depletion Triggers in Human Cell Lines, Associated with Improving Responses to Cancer Therapy Save
- Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities Save
- Mutational studies on Leishmania donovani dihydrolipoamide dehydrogenase (LdBPK291950.1) indicates that the enzyme may not be classical class-I pyridine nucleotide-disulfide oxidoreductase Save
- BLIMP-1 Mediated Downregulation of TAK1 and p53 Molecules Is Crucial in the Pathogenesis of Kala-Azar Save
- Virus-like particles: nano-carriers in targeted therapeutics Save
- BLIMP-1 Plays Important Role in the Regulation of Macrophage Pyroptosis for the Growth and Multiplication of Leishmania donovani Save
- Biochemical characterization and chemical validation of Leishmania MAP Kinase-3 as a potential drug target Save
- Leishmania donovani evades Caspase 1 dependent host defense mechanism during infection Save
- Biochemical characterization of a stable azoreductase enzyme from Chromobacterium violaceum: Application in industrial effluent dye degradation Save
- Episomal expression of human glutathione reductase (HuGR) in Leishmania sheds light on evolutionary pressure for unique redox metabolism pathway: Impaired stress tolerance ability of Leishmania donovani Save
- Apoptosis: Mediator Molecules, Interplay with Other Cell Death Processes and Therapeutic Potentials Save
- Cloning, expression and characterization ofBrugia malayiabundant larval protein transcript-2 (BmALT-2) expressed inPichia pastoris Save
- Novel Agents against Miltefosine-Unresponsive Leishmania donovani Save