Nagesh C. Shanbhag

About

My research addresses a fundamental question in neuroscience and clinical medicine: How does the brain clear metabolic waste under physiological stress and disease, and can this process be actively modulated in humans?

I specialize in the glymphatic system and cerebrospinal fluid (CSF) dynamics, integrating cerebrovascular pulsatility, brain compliance, autonomic regulation, and neuroimmune drainage. My goal is to develop mechanistically grounded, non-pharmacological interventions for CNS disorders.

Clinical Research: Multimodal Neuromonitoring | Neurofluids-Solute Imaging | Neurosurgical Implications
Contributed to the NIHR-funded RESCUE-ASDH trial (Global Neurotrauma group) at the NIMHANS-Neurosurgery, Bengaluru study site.

Preclinical Expertise: Skilled in rodent and large mammal models to investigate CNS disease pathophysiology.

Core Interests: Neurofluids | Brain Clearance | Photobiomodulation | EECP | CNS-Peripheral Connection | Yogic Breathing & Nature-based Interventions.

Background: Doctor of Philosophy (PhD) in Neurosciences, University of Groningen, The Netherlands; MSc in Neurosciences, University of Regensburg, Germany; Basic Medical Studies (MBBS), Goa University, India.

Employment

• Meditech Foundation Research Physician
  2025 - Present
• ProNeuroLIGHT LLC External Consultant (Research Services)
  2023 - Present
• Jawaharlal Institute of Post Graduate Medical Education and Research Clinical Research Fellow
  2023 - 2024
• Lund University Postdoctoral fellow
  2019 - 2022
• National Institute of Mental Health and Neuro Sciences Clinical Research Fellow
  2018 - 2019
• Uniformed Services University of the Health Sciences Postdoctoral fellow
  2016 - 2017

Education

• University of Groningen PhD
  2013 - 2016
• University of Heidelberg PhD
  2010 - 2013
• University of Regensburg MSc
  2008 - 2010
• Goa Medical College MBBS
  2001 - 2007

Projects & Funding

Projects & funding information is unavailable.

Publications (25)

• Functional aspects of cerebrospinal fluid drainage through the cribriform plate
  Brain Communications 2026 DOI: 10.1093/braincomms/fcag308
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• The electrofluidic brain as a basement layer for neural computation
  Communications Biology 2026 DOI: 10.1038/s42003-026-10444-0
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• Brain clearance physiology in traumatic brain injury: From disruption to therapeutic potential
  The Journal of Physiology 2026 DOI: 10.1113/JP291237
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• Radiolabeling and preclinical evaluation of technetium-99m labeled colistin
  Applied Radiation and Isotopes 2024 DOI: 10.1016/j.apradiso.2024.111524
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• Decompressive craniectomy in children: indications and outcome from a tertiary centre
  Child's Nervous System 2024 DOI: 10.1007/s00381-024-06513-6
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• Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep
  Journal of Cerebral Blood Flow & Metabolism 2021 DOI: 10.1177/0271678x211033358
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• Impaired cerebrospinal fluid transport due to idiopathic subdural hematoma in pig: an unusual case
  BMC Veterinary Research 2021 DOI: 10.1186/s12917-021-02954-2
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• Direct Cannula Implantation in the Cisterna Magna of Pigs
  Journal of Visualized Experiments 2021 DOI: 10.3791/62641
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• Glymphatic pathways in the gyrencephalic brain.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2021 DOI: 10.1177/0271678x21996175
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• Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective
  J Cereb Blood Flow Metab 2021 DOI: 10.1177/0271678X20982388
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