KN

Kim E. Nichols

Also known as: Nichols KE

St. Jude Children's Research Hospital, University of Pennsylvania Perelman School of Medicine, Massachusetts General Hospital, Dana-Farber Cancer Institute, Harvard University School of Medicine

Research areas: Biochemistry, Genetics and Molecular Biology · Genetics · BRCA gene mutations in cancer · Immunodeficiency and Autoimmune Disorders · Cancer Genomics and Diagnostics

ORCID iD 0000-0002-5581-6555
Follow

Employment

  • St. Jude Children's Research Hospital Full Member
    2014 - Present
  • St. Jude Children's Research Hospital Director
    2014 - Present
  • University of Pennsylvania Perelman School of Medicine Associate Professor
    2007 - 2014
  • University of Pennsylvania Perelman School of Medicine Assistant Professor
    1999 - 2007
  • Harvard University School of Medicine Attending Physician
    1995 - 1999
  • University of Pennsylvania Perelman School of Medicine Director
    1995 - 1999
  • Boston Children's Hospital Instructor in Medicine
    1995 - 1999

Education

Projects & Funding

  • Towards a Unified Platform for Li-Fraumeni Syndrome Cancer Risk Protection and Cell-free DNA Surveillance The Mark Foundation for Cancer Research
    2026 - 2028
  • In vitro validation of variants of uncertain significance in the genes associated with HLH Histiocytosis Association
    2025 - 2026
  • Validation of a novel tool for predicting pathogenicity of VUS in familial HLH genes Jeffrey Modell Foundation
    2024 - 2026
  • Immunoproteasome inhibition in HLH Histiocytosis Association
    2023 - 2024
  • Barriers and facilitators of parent-child communication in children with cancer predisposition American Cancer Society
    2023 - 2026
  • Targeting the immunoproteasome as a novel therapeutic strategy for hemophagocytic lymphohistiocytosis National Institute of Allergy and Infectious Diseases
    2023 - 2026
  • Pathogenesis of ETV6-Related Acute Lymphoblastic Leukemia National Cancer Institute
    2020 - 2026
  • Pathogenesis of ETV6-related acute lymphoblastic leukemia Division of Cancer Epidemiology and Genetics, National Cancer Institute
    2020 - 2026
  • Consortium for Childhood Cancer Predisposition St. Baldrick's Foundation
    2020 - 2026
  • Consortium for Childhood Cancer Predisposition St. Baldrick's Foundation
    2019 - 2020
  • Pathogenesis of ETV6-Related Acute Lymphoblastic Leukemia American Society of Hematology
    2019 - 2021
  • Therapy with ruxolitinib and dexamethasone in HLH Cures Within Reach
    2019 - 2025
  • iPSC-based systems to study predisposition to B-ALL St. Jude Children's Research Hospital
    2018 - 2020
  • Community-based STEM professional learning for teachers of middle years Australian Research Council
    2018 - 2021
  • Genomic analysis of familial leukemia National Institutes of Health
    2016 - 2017
  • The St. Jude Lifetime Cohort St. Jude Children's Research Hospital
    2015 - 2020
  • JAK inhibition as a novel treatment for hemophagocytic lymphohistiocytosis National Institute of Allergy and Infectious Diseases
    2014 - 2016
  • Janus kinase inhibition in HLH Histiocytosis Association
    2014 - 2016
  • JAK inhibition in HLH University of Pennsylvania
    2014 - 2015
  • Genetic studies in cancer predisposition CHOP
    2014 - 2015
  • Consortium for Clinical and Translational Research in LCH St. Baldrick's Foundation
    2014 - 2016
  • Tumor targeting of iNKT cells using a novel CD1d-CD19 fusion protein SAS Foundation
    2013 - 2014
  • Immunogenomics to create new therapies for high-risk childhood cancers St. Baldrick's Foundation
    2013 - 2017
  • Cytokine directed therapies in HLH CHOP
    2013 - 2014
  • JAK inhibition in the treatment of HLH CHOP
    2013 - 2014
  • NKT cell anti-leukemia therapies University of Pennsylvania
    2013 - 2013
  • iNKT cell-based cancer therapies CHOP
    2012 - 2014
  • Adolescent perspectives regarding genetic testing for Li-Fraumeni Syndrome CHOP
    2012 - 2014
  • Early Identification & Linkage to Care for Persons w/Chronic HBV & HCV Infections Centers for Disease Control and Prevention
    2012 - 2014
  • 2012 Summer Fellowship Award St. Baldrick's Foundation
    2012 - 2012
  • Transforming primary teachers' representational practices: effects on students' scientific reasoning and discourse within contemporary sciences Australian Research Council
    2011 - 2014
  • Parent communication about TP53 genetic testing University of Pennsylvania
    2011 - 2014
  • NKT cells and control of EBV CHOP
    2011 - 2012
  • Communication about childhood cancer risk CHOP
    2011 - 2012
  • Pediatric Developmental Funds CHOP
    2010 - 2011
  • Comparative effectiveness of two strategic and meta-cognitive questioning approaches on children's explanatory behaviour, problem-solving, and learning during cooperative, inquiry-based learning Australian Research Council
    2008 - 2011
  • Regulation of NKT cell development by SAP XLP Research Trust Award
    2008 - 2010
  • Application of genomic approaches to classify Retinoblastoma National Institutes of Health
    2007 - 2010
  • Transforming the technologies and modalities of learning: The case of the New Life Sciences in secondary schooling Australian Research Council
    2007 - 2012
  • Roles of SAP, SLAM and Fyn in NKT cell ontogeny and activation National Institutes of Health
    2007 - 2013
  • Parental genotypes and exposures in sporadic Retinoblastoma National Institutes of Health
    2007 - 2013
  • Role of SAP,SLAM and Fyn in NKT Cell Ontogeny and Activation National Heart, Lung, and Blood Institute
    2007 - 2014
  • Role of SAP,SLAM and Fyn in NKT Cell Ontogeny and Activation National Heart Lung and Blood Institute
    2007 - 2014
  • SH2D1A/SAP in NKT development and activation National Institutes of Health
    2004 - 2009
  • Regulation of PMN activation by SLP-76, PRAM-1 and ADAP National Institutes of Health
    2004 - 2010
  • SH2D1A genotype and T/B phenotype in XLP United States Immunodeficiency Network
    2004 - 2007
  • ROLE OF SH2D1A/SAP IN NKT CELL DEVELOPMENT AND FUNCTION National Heart, Lung, and Blood Institute
    2004 - 2009
  • Regulation of T lymphocyte function by SH2D1A American Society of Hematology
    2002 - 2004
  • Institutional Research Grant American Cancer Society
    2001 - 2003
  • Evaluation of retinoblastomas for mutations in RB1 American Cancer Society
    2000 - 2001
  • Detection of germline mutations in hereditary retinoblastoma W. W. Smith Charitable Trust
    2000 - 2001
  • Characterization of the 2B4 pathway in XLP Histiocytosis Association
    2000 - 2001
  • Characterisation of the distribution and role of voltage-gated calcium channels in autonomic neurons National Health and Medical Research Council
    1999 - 2003
  • Genetic predisposition to second malignancies Dana-Farber Cancer Institute
    1997 - 1999
  • Establishing a histiocytosis research program Dana-Farber Cancer Institute
    1997 - 1999
  • Isolation of the XLP gene National Institutes of Health
    1995 - 2001
  • Neuronal basis for the triggering of intestinal peristalsis International Human Frontier Science Program Organization
    1995 - 1998
  • IDENTIFICATION OF THE XLP GENE National Institute of Allergy and Infectious Diseases
    1995 - 2001
  • Genome Remodeling in Developmental Cancers National Cancer Institute
  • Mechanisms of Immune Dysregulation Disorders Underlying Inborn errors of the Cytolytic Pathway National Institute of Allergy and Infectious Diseases
  • Targeting thProtein Arginine Methyltransferase 5 Enzyme in Hemophagocytic Lymphohistiocytosis National Institutes of Health

Publications (310)