Amardeep Kumar

About

Amardeep Kumar is a postdoctoral fellow at the National Cancer Institute (NCI), NIH, specializing in protein engineering, biocatalysis, and chemical biology. He earned his Ph.D. in Chemistry from Indiana University Bloomington, where his research focused on engineering B12-dependent enzymes for non-native alkylation, and radical transformations. His work integrates protein engineering, mechanistic enzymology, directed evolution, and computational protein design to develop biocatalysts with new-to-nature functions. His current research focuses on antibody and nanobody discovery and AI/ML-guided protein engineering for cancer-targeted therapeutics. His broader research interests include protein engineering, biocatalysis, synthetic biology, computational protein design, and the development of engineered biomolecules for applications in sustainable chemistry and cancer therapeutics for better human health.

Employment

• National Cancer Institute Postdoctoral Fellow
  2026 - Present
• Indiana University PhD
  2021 - 2026

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (7)

• Nonnative Thiol and Aniline Methylation, Including Enantioselective Dithiol Desymmetrization, by Multicomponent Cobamide‐Dependent Methyltransferases Using Unactivated Methyl Donors
  Angewandte Chemie International Edition 2026 DOI: 10.1002/anie.1537547
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• Nonnative Thiol and Aniline Methylation, Including Enantioselective Dithiol Desymmetrization, by Multicomponent Cobamide‐Dependent Methyltransferases Using Unactivated Methyl Donors
  Angewandte Chemie 2026 DOI: 10.1002/ange.1537547
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• The Expanding Reactivity of Cobamide-Containing Proteins: From Mechanistic Understanding to Non-Native Biocatalysis
  ACS Catalysis 2026 DOI: 10.1021/acscatal.6c03394
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• Non-Native Thiol and Aniline Methylation, Including Enantioselective Dithiol Desymmetrization, by Multi-Component Cobamide-Dependent Methyltransferases Using Unactivated Methyl Donors
  2026 DOI: 10.26434/chemrxiv.15002482/v2
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• Non‐native Intramolecular Radical Cyclization Catalyzed by a B12‐Dependent Enzyme**
  Angewandte Chemie International Edition 2023 DOI: 10.1002/anie.202312893
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• First and Second Sphere Interactions Accelerate Non-Native N-Alkylation Catalysis by the Thermostable, Methanol-Tolerant B12-Dependent Enzyme MtaC
  Chemical Communications 2023 DOI: 10.1039/D3CC01071F
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• Controlling Non-Native Cobalamin Reactivity and Catalysis in the Transcription Factor CarH
  ACS Catalysis 2022 DOI: 10.1021/acscatal.1c04748
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