Rajarshi Ghosh

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Publications (16)

• Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer’s disease
  Science Translational Medicine 2025 6 citations DOI: 10.1126/scitranslmed.adw7428
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• LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.
  Molecular neurodegeneration 2025 8 citations DOI: 10.1186/s13024-025-00880-7
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• Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
  eLife 2023 50 citations DOI: 10.7554/elife.87255
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• Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease.
  Science translational medicine 2022 263 citations DOI: 10.1126/scitranslmed.abj2658
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• ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR
  Nature Chemical Biology 2021 33 citations DOI: 10.1038/s41589-021-00852-0
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• Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.
  Cancer research 2019 35 citations DOI: 10.1158/0008-5472.can-19-1116
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• Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes.
  Molecular metabolism 2019 113 citations DOI: 10.1016/j.molmet.2019.06.012
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• Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.
  PloS one 2019 68 citations DOI: 10.1371/journal.pone.0209824
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• Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.
  Cell metabolism 2017 184 citations DOI: 10.1016/j.cmet.2017.03.018
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• Combined modulation of IRE1
  2017
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