Dr. Shah Alam

About

Welcome to my profile! I'm a dedicated molecular biologist with a fascination for understanding the brain's complexities. With expertise in molecular biology and neuroscience, I strive to advance our knowledge of neurological processes.

My academic voyage encompasses a Ph.D. in neuroscience granted by the University of Bonn, Germany, succeeded by a Postdoc specialization in RNA Biology at Columbia University in New York. During my tenure in Bonn, my research revolved around deciphering neural signaling and exploring epigenetic mechanisms in mouse models of neurodegenerative diseases. Presently, my endeavors involve pioneering techniques such as CRISPR-Cas9 and single-cell transcriptomics to delve into these subjects.

I hold a deep appreciation for collaborative efforts and the mentor-mentee dynamic, recognizing that diverse partnerships are the catalysts for groundbreaking revelations. I invite you to accompany me in pushing the boundaries of neuroscience and molecular biology, ultimately contributing to the enhancement of human lives. Let's unite our efforts and embark on a journey to explore new horizons together.

Research Area: Neuroscience / Moecular Biology
Technical Expertise: Molecular biology and Biochemistry
Instrument: LC-MS, Flow Cytometry, HPLC and Confocal Fluorescence Microscope, ÄKTA Pure system 25

Employment

• Columbia University Department of Systems Biology Postdoctoral Research Scientist
  2023 - Present
• Rheinische Friedrich-Wilhelms-Universität Bonn Post doctoral Scientist
  2021 - 2023

Education

• Rheinische Friedrich-Wilhelms-Universität Bonn Ph.D.
  2017 - 2021

Projects & Funding

Projects & funding information is unavailable.

Publications (11)

• A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability
  Nature Communications 2026 DOI: 10.1038/s41467-026-69486-x
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• A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability
  2025 DOI: 10.64898/2025.12.12.693948
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• S1P Lyase Deficiency in the Brain Promotes Astrogliosis and NLRP3 Inflammasome Activation via Purinergic Signaling
  Cells 2023 DOI: 10.3390/cells12141844
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• S1P Released by SGPL1-Deficient Astrocytes Enhances Astrocytic ATP Production via S1PR2,4, Thus Keeping Autophagy in Check: Potential Consequences for Brain Health
  International Journal of Molecular Sciences 2023 DOI: 10.3390/ijms24054581
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• Sphingosine‐1‐phosphate‐lyase deficiency affects glucose metabolism in a way that abets oncogenesis
  Molecular Oncology 2022 DOI: 10.1002/1878-0261.13300
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• Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation
  Cells 2020 DOI: 10.3390/cells9102189
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• S1P-lyase deficiency uncouples ganglioside formation – Potential contribution to tumorigenic capacity
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2020 DOI: 10.1016/j.bbalip.2020.158708
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• Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation
  Glia 2019 DOI: 10.1002/glia.23663
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• Sphingolipid metabolism – an ambiguous regulator of autophagy in the brain
  Biological Chemistry 2018 DOI: 10.1515/hsz-2018-0237
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• Studies on Growth Kinetics of Serratia marcescens VITSD2 and Optimization of Fermentation Conditions for Serratiopeptidase Production
  Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2014 DOI: 10.2174/1871523013666140627120717
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