Bhrugu Yagnik

About

I am a biomedical researcher with 7+ years of experience in Immunology, Molecular Biology, Microbiology and Biotechnology. I have extensive knowledge on the development of mucosal vaccines against pathogens such as Shigella, Salmonella and HIV. I have also explored a food grade organism Lactococcus lactis (L. lactis) as an antigen and DNA delivery vehicle. Currently, I am working on the development of therapeutic HIV/AIDS vaccine with the aim to strengthen the mucosal immune responses, essential to prevent HIV infection.

Employment

• Thermo Fisher Scientific (United States) MSL and Scientific Partnerships Manager
  2024 - Present
• Yerkes National Primate Research Center Postdoctoral Research Fellow
  2018 - Present
• Society for Research and Initiatives for Sustainable Technologies and Institutions Research Associate
  2017 - 2018
• M G Science Institute Visiting Lecturer
  2014 - 2017
• B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre Research Fellow
  2012 - 2017

Education

• Sardar Patel University PhD (Biotechnology)
  2013 - 2018
• The Maharaja Sayajirao University of Baroda M.Sc. Biochemistry
  2010 - 2012
• M. G. Science Institute B.Sc. Biochemistry
  2007 - 2010

Projects & Funding

• Use of Lactococcus lactis for development of diarrheal vaccine International Society For Vaccines
  2016 - 2016
• Use of Lactococcus lactis for development of diarrheal vaccine Department of Science and Technology, Ministry of Science and Technology
  2016 - 2016
• Use of Lactococcus lactis for development of diarrheal vaccine Lady Tata Memorial Trust

Publications (19)

• Addressing Diagnostics Delay in Multiple Myeloma: Insights from a National Survey of Primary Care Providers
  The Journal of Applied Laboratory Medicine 2026 DOI: 10.1093/jalm/jfag087
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• Identifying correlates of viral rebound timing and viral control in SHIV-infected infant macaques after ART interruption
  Science Translational Medicine 2025 DOI: 10.1126/scitranslmed.adq1965
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• A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence.
  PLoS pathogens 2022 DOI: 10.1371/journal.ppat.1010488
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• PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8 + T cells in lymphoid tissue
  Science Immunology 2021 DOI: 10.1126/sciimmunol.abh3034
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• Oral immunization with LacVax® OmpA induces protective immune response against Shigella flexneri 2a ATCC 12022 in a murine model
  Bhrugu Yagnik, Drashya Sharma, Harish Padh

  +1 more

  • Priti N Desai
  Vaccine 2019 DOI: 10.1016/j.vaccine.2019.04.053
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• LacVax (R): OmpA- an affordable food grade vaccine platform against Shigella
  European Journal of Immunology 2019
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• Oral immunization with LacVax (R) OmpA induces protective immune response against Shigella flexneri 2a ATCC 12022 in a murine model
  Vaccine 2019
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• In vivo delivery of pPERDBY to BALB/c mice by LacVax® DNA-I and comparison of elicited immune response with conventional immunization methods
  Bhrugu Yagnik, Drashya Sharma, Harish Padh

  +1 more

  • Priti N Desai
  Gene Therapy 2018 DOI: 10.1038/s41434-018-0033-8
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• Microbubble-Mediated Enhanced Delivery of Curcumin to Cervical Cancer Cells
  Awaneesh Upadhyay, Bhrugu Yagnik, Priti N Desai

  +1 more

  • Sameer V. Dalvi
  ACS Omega 2018 DOI: 10.1021/ACSOMEGA.8B01737
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• Dual recombinant Lactococcus lactis for enhanced delivery of DNA vaccine reporter plasmid pPERDBY.
  Bhrugu Yagnik, Drashya Sharma, Harish Padh

  +1 more

  • Priti N Desai
  2017 DOI: 10.1111/1348-0421.12473
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• Immunization with r-Lactococcus lactis expressing outer membrane protein A of Shigella dysenteriae type-1: evaluation of oral and intranasal route of administration.
  Bhrugu Yagnik, Drashya Sharma, Harish Padh

  +1 more

  • Priti N Desai
  2017 DOI: 10.1111/jam.13353
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• Shigellosis murine model established by intraperitoneal and intranasal route of administration: a comparative comprehension overview.
  Drashya Sharma, Bhrugu Yagnik, Ruma Baksi

  +3 more

  • Nirav Desai
  • Harish Padh
  • Priti N Desai
  2017 DOI: 10.1016/j.micinf.2016.09.002
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• Association of dental and skeletal fluorosis with calcium intake and serum vitamin D concentration in adolescents from a region endemic for fluorosis.
  2017 DOI: 10.4103/2230-8210.196013
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• Transfecting CHO-K1 Cells: Comparison of CaPO4, Electroporation and Lipoplex Method with In-house Prepared Polyplex
  Priti N Desai, Bhrugu Yagnik, Drashya Sharma

  +3 more

  • Abdul Raheman Khan
  • N Desai
  • Harish Padh
  Indian Journal of Pharmaceutical Sciences 2017 DOI: 10.4172/PHARMACEUTICAL-SCIENCES.1000276
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• Construction of a new shuttle vector for DNA delivery into mammalian cells using non-invasive Lactococcus lactis.
  Bhrugu Yagnik, Harish Padh, Priti N Desai
  2016 DOI: 10.1016/j.micinf.2015.11.006
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• NUTRITIONAL STATUS ASSESSMENT OF WOMEN FROM DIFFERENT OCCUPATIONS IN URBAN AND SEMI-URBAN REGIONS OF GUJARAT
  International Journal of Food and Nutritional Science 2016 DOI: 10.15436/2377-0619.16.1239
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• Factors Affecting Inducible Expression of Outer Membrane Protein A (OmpA) of Shigella dysenteriae Type-1 in Lactococcus lactis Using Nisin Inducible Controlled Expression (NICE)
  Bhrugu Yagnik, Shivangi Patel, Maitree Dave +3 more
  Indian J Microbiol 2015 DOI: 10.1007/s12088-015-0556-2
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• Dietary calcium intake influences the relationship between serum 25-hydroxyvitamin D3 (25OHD) concentration and parathyroid hormone (PTH) concentration.
  2015 DOI: 10.1136/archdischild-2015-308985
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• Association of dental and skeletal fluorosis with calcium intake and vitamin D concentrations in adolescents from a region endemic for fluorosis
  BA 2015 DOI: 10.1530/boneabs.4.p62
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