Crispin Hiley

Employment

• University College London Hospitals NHS Foundation Trust Consultant Clinical Oncologist
  2018 - Present
• University College London Associate Professor
  2018 - Present
• The Francis Crick Institute Visiting Scientist
  2018 - Present

Education

Education history is unavailable.

Projects & Funding

• Cancer Genetics & Epidemiology: From biological resource centres to functional studies Cancer Research UK
  2007 - 2007
• CRUK Clinical Post Doctoral Research GRant Cancer Research UK

Publications (28)

• The concept of virtual clinical trials: A game changer in radiation oncology research?
  Radiotherapy and Oncology 2026 DOI: 10.1016/j.radonc.2025.111264
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• The Interaction of Preexisting Cardiac Dysfunction and Heart Dose From Radical Radiotherapy on All-Cause Mortality in Locally Advanced NSCLC
  Journal of Thoracic Oncology 2023 DOI: 10.1016/j.jtho.2022.10.017
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• Great debate: surgery versus stereotactic radiotherapy for early-stage non-small cell lung cancer
  Thorax 2020 DOI: 10.1136/thoraxjnl-2019-214014
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• Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution (Nature (2017) 545 (446-451) DOI: 10.1038/nature22364)
  Nature 2018 DOI: 10.1038/nature25161
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• Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies
  Frederick Arce Vargas, Andrew J.S. Furness, Kevin Litchfield +97 more
  Cancer Cell 2018 DOI: 10.1016/j.ccell.2018.02.010
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• Is heterogeneity in stage 3 non-small cell lung cancer obscuring the potential benefits of dose-escalated concurrent chemo-radiotherapy in clinical trials?
  Lung Cancer 2018 DOI: 10.1016/j.lungcan.2018.02.006
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• Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
  Cell 2017 DOI: 10.1016/j.cell.2017.10.001
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• Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors
  Immunity 2017 DOI: 10.1016/j.immuni.2017.03.013
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• Intratumoural evolutionary landscape of high-risk prostate cancer: The PROGENY study of genomic and immune parameters
  Annals of Oncology 2017 DOI: 10.1093/annonc/mdx355
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• Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
  Nature 2017 DOI: 10.1038/nature22364
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• Tracking the evolution of non-small-cell lung cancer
  New England Journal of Medicine 2017 DOI: 10.1056/NEJMoa1616288
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• Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease
  The Lancet 2016 DOI: 10.1016/S0140-6736(16)31340-X
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• Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
  Science 2016 DOI: 10.1126/science.aaf1490
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• Pruning cancer’s evolutionary tree with lesion-directed therapy
  Cancer Discovery 2016 DOI: 10.1158/2159-8290.CD-15-1493
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• Can oncology recapitulate paleontology? Lessons from species extinctions
  Nature Reviews Clinical Oncology 2015 DOI: 10.1038/nrclinonc.2015.12
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• Cognitive impairment in survivors of irradiated brain tumors is multifactorial: Implications of polypharmacy with antiepileptics?
  Journal of Clinical Oncology 2015 DOI: 10.1200/JCO.2015.62.5350
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• Evolutionary precision medicine: A role for repeat epidermal growth factor receptor analysis in ALK-rearranged lung adenocarcinoma?
  Journal of Clinical Oncology 2015 DOI: 10.1200/JCO.2015.63.2976
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• Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
  Genome Biology 2014 DOI: 10.1186/s13059-014-0453-8
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• Spatial and temporal cancer evolution: causes and consequences of tumour diversity
  Clinical medicine (London, England) 2014 DOI: 10.7861/clinmedicine.14-6-s33
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• Breast reconstruction and post-mastectomy radiation practice
  Radiation Oncology 2013 DOI: 10.1186/1748-717X-8-45
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