Simoben CV

About

Born in 1990 in Cameroon. Obtained my BSc and MSc degrees in Chemistry after successful studies during the academic years 2008-2011 and 2012-2015 respectively, at the University of Buea, Cameroon. currently I'm working for a PhD degree focused on the Search for Natural Products (NPs) Inhibitors and Modulators of Epigenetic Targets in Anti-malarial Drug Discovery and the development of NPs databases for compounds isolated from African medicinal plants. currently a research student at MLU, Halle.

Employment

Employment history is unavailable.

Education

• Martin Luther Universität Halle-Wittenberg Institut für Pharmazie PhD ...
  2016 - Present
• University of Buea Faculty of Sciences M.Sc. Chemistry
  2012 - 2015
• University of Buea Faculty of Science B.Sc. Chem
  2008 - 2011

Projects & Funding

Projects & funding information is unavailable.

Publications (44)

• The pan-African natural products library compounds oleanolic acid, poinsettifolin B, and rhuschalcone III disrupt SARS-CoV-2 spike-host ACE2 interactions and SARS-CoV-2 replication
  BMC Pharmacology and Toxicology 2026 DOI: 10.1186/s40360-026-01264-3
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• Unveiling of promising DprE1 inhibitor hits from our designed virtual library and Africa natural products database through integrated computational approaches
  Scientific African 2026 DOI: 10.1016/j.sciaf.2026.e03407
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• Natural Products in Gambeya lacourtiana (Sapotaceae): Identification, In Vitro Cytoxicity, and Deep Learning‐Based Pharmacokinetic Prediction
  Chemistry & Biodiversity 2026 DOI: 10.1002/cbdv.202502045
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• The Pan-African Natural Products Library Compounds Oleanolic Acid, Poinsettifolin B, and Rhuschalcone III Disrupt SARS-CoV-2 Spike-Host ACE2 Interactions and SARS-CoV-2 Replication
  2026 DOI: 10.20944/preprints202602.1425.v1
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• African Natural Products Database (ANPDB): A resource for exploring the therapeutic potential of natural compounds from Africa
  Nucleic Acids Research 2026 DOI: 10.1093/nar/gkaf1186
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• Integrated in silico approaches for the identification of promising dual-target inhibitors of Mycobacterium tuberculosis DprE1 and InhA enzymes
  In Silico Research in Biomedicine 2026 DOI: 10.1016/j.insi.2026.100571
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• Enantioselective protein affinity selection mass spectrometry (E-ASMS)
  Nature Communications 2025 DOI: 10.1038/s41467-025-67403-2
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• Iboga‐Indole Alkaloids as Potential Plasmodial Inhibitors: Identification, Biosynthesis, and Molecular Docking Studies
  Chemistry & Biodiversity 2025 DOI: 10.1002/cbdv.202501035
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• Identification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 Complex
  Rocher Leung, Esther Wolf, Justin C. Deme +19 more
  2025 DOI: 10.1101/2025.11.21.689733
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• Natural Products in Cyperus Species (Cyperaceae): Phytochemistry, Pharmacological Activities, and Biosynthesis
  Smith B. Babiaka, Doris E. Ekayen, Conrad Veranso Simoben +13 more
  Chemistry & Biodiversity 2025 DOI: 10.1002/cbdv.202403352
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• StreptomeDB 4.0: a comprehensive database of streptomycetes natural products enriched with protein interactions and interactive spectral visualization
  Nucleic Acids Research 2025 DOI: 10.1093/nar/gkae1030
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• Computational discovery of dual potential inhibitors of SARS‐CoV‐2 spike/ACE2 and Mpro: 3D-pharmacophore, docking-based virtual screening, quantum mechanics and molecular dynamics
  European Biophysics Journal 2024 DOI: 10.1007/s00249-024-01713-z
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• Emerging structure-based computational methods to screen the exploding accessible chemical space
  Current Opinion in Structural Biology 2024 DOI: 10.1016/j.sbi.2024.102812
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• 5-chloro-3-(2-(2,4-dinitrophenyl) hydrazono)indolin-2-one: synthesis, characterization, biochemical and computational screening against SARS-CoV-2
  Felicite Majoumo‐Mbe, Neba Abongwa Sangbong, Alain Tadjong Tcho

  +10 more

  • Cyril T. Namba-Nzanguim
  • Conrad Veranso Simoben
  • Donatus Bekindaka Eni
  • Mustafa Alhaji Isa
  • Adi Narayana Reddy Poli
  • +5 more
  Chemical Papers 2024 DOI: 10.1007/s11696-023-03274-5
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• Design, synthesis, and biochemical and computational screening of novel oxindole derivatives as inhibitors of Aurora A kinase and SARS-CoV-2 spike/host ACE2 interaction
  Donatus Bekindaka Eni, Joel A. Cassel, Cyril T. Namba-Nzanguim

  +5 more

  • Conrad Veranso Simoben
  • Ian Tietjen
  • Ravikumar Akunuri
  • Joseph M. Salvino
  • Fidele Ntie‐Kang
  Medicinal Chemistry Research 2024 DOI: 10.1007/s00044-024-03201-7
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• Challenges in natural product-based drug discovery assisted with in silico-based methods
  RSC Advances 2023 DOI: 10.1039/D3RA06831E
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• Artificial intelligence for antiviral drug discovery in low resourced settings: A perspective
  Frontiers in Drug Discovery 2022 DOI: 10.3389/fddsv.2022.1013285
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• Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis
  European Journal of Medicinal Chemistry 2021 DOI: 10.1016/j.ejmech.2021.113745
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• Strategies To Design Selective Histone Deacetylase Inhibitors
  ChemMedChem 2021 DOI: 10.1002/cmdc.202000934
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• Binding Free Energy (BFE) Calculations and Quantitative Structure–Activity Relationship (QSAR) Analysis of Schistosoma mansoni Histone Deacetylase 8 (smHDAC8) Inhibitors
  Molecules 2021 DOI: 10.3390/molecules26092584
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