Prerna Sharma
Geisinger Commonwealth School of Medicine, Arizona State University, Institute of Microbial Technology, Indian Institute of Technology Bombay
0000-0002-6195-8082
About
I am an associate professor of biochemistry and physiology at Geisinger Commonwealth School of Medicine. I conduct research on discovering biomolecules for targeted therapies and diagnostics in my lab. Among my medical education research interests are health equity and sex and gender-based medicine.
I completed her postdoctoral fellowship in protein engineering from the Biodesign Institute at Arizona State University in Tempe, Arizona. I received my PhD in protein biochemistry, biophysics, and molecular biology from Institute of Microbial Technology (a national lab in India). After completing my PhD in 2015, I was selected as a national scholar to conduct research at the Indian Institute of Technology, Bombay, India where I worked on enzyme engineering and process optimization. Her areas of research expertise are in antibody engineering, glycobiology, protein biochemistry and its engineering. I am trained in both rational and directed evolution methods to modify the scaffolds of different proteins to assess their affinities and properties for improved function. Among my research interests are developing protein-based therapeutics, understanding the structure-function relationship of enzymes and proteins/membrane protein complexes involved in cellular metabolism.
I have mentored more than 10 medical students in my lab through the Medical Honors Research Program, the Summer Research Internship Program and the GCSOM Biomedical Research Club. Current research interests includes characterizing engineered single chain antibodies for improved manufacturability and novel lectins (glycan-binding proteins) for their anti-bacterial, anti-viral and anti-tumor properties. I am working to explore the areas of improvement in medical science curriculum to incorporate sex and gender-based medicine and health equity.
Employment
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Geisinger Commonwealth School of Medicine Assistant Professor-Biochemistry and Physiology2020 - Present
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Arizona State University Postdoctoral Research Associate2017 - 2020
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Indian Institute of Technology Bombay Postdoctoral Research Associate2016 - 2017
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Indian Institute of Science Education and Research Mohali Postdoctoral research associate2015 - 2016
Education
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Institute of Microbial Technology PhD2009 - 2015
Projects & Funding
Projects & funding information is unavailable.
Publications (21)
- N-Heterocyclic imine derived green Catalyst P2ML2 shows moderate binding with domain IB of human serum albumin Save
- Biophysical insights into sodium lauroyl sarcosine induced amyloid fibrillation of human serum albumin Save
- Hexametaphosphate, a Common Food Additive, Aggregated the Hen Egg White Lysozyme Save
- Therapeutic Antibodies in Medicine Save
- Anionic surfactant causes dual conformational changes in insulin Save
- Interaction Mechanism between α-Lactalbumin and Caffeic Acid: A Multispectroscopic and Molecular Docking Study Save
- Examining the effect of removing a conserved disulfide bond on the structural stability and activity of a lysozyme-specific nanobody Save
- Track: Protein Science Addressing Health Disparities An engineered disulfide-free antibody against norfloxacin Save
- Design of novel cyanovirin-N variants by modulation of binding dynamics through distal mutations Save
- Core Concepts as a Framework to Assess the Progression of Student Learning in a Ume Curriculum Save