LOUISE JANE GOURLAY

Employment

• Università degli Studi di Milano Assistant Professor in Biochemistry
  2018 - Present

Education

• University of Dundee BSc(Hons) Pharmacology and Biochemistry
  1995 - 1999

Projects & Funding

Projects & funding information is unavailable.

Publications (43)

• NFIX missense variants that disrupt the β-hairpin loop result in a severe form of Malan syndrome in adolescence with rapidly evolving scoliosis and muscle wasting
  2026 DOI: 10.64898/2026.07.16.26357549
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• Structural basis of Nuclear Factor 1-X DNA recognition provides prototypic insight into the NFI family
  Michele Tiberi, Michela Lapi, Louise J. Gourlay +17 more
  Nature Communications 2025 DOI: 10.1038/s41467-025-65186-0
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• Structural determinants of cold activity and glucose tolerance of a family 1 glycoside hydrolase (GH1) from Antarctic Marinomonas sp. ef1
  The FEBS Journal 2024 DOI: 10.1111/febs.17096
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• Solution Structure of the BPSL1445 Protein of Burkholderia pseudomallei Reveals the SYLF Domain Three-Dimensional Fold
  ACS Chemical Biology 2022 DOI: 10.1021/acschembio.1c00886
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• Elucidating the 3D Structure of a Surface Membrane Antigen from Trypanosoma cruzi as a Serodiagnostic Biomarker of Chagas Disease
  Vaccines 2022 DOI: 10.3390/vaccines10010071
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• Epidemic preparedness - Leishmania tarentolae as an easy-to-handle tool to produce antigens for viral diagnosis: application to COVID-19
  2021 DOI: 10.1101/2021.07.05.21260035
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• Structure, Immunoreactivity, and In Silico Epitope Determination of SmSPI S. mansoni Serpin for Immunodiagnostic Application
  Vaccines 2021 DOI: 10.3390/vaccines9040322
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• Uncommon overoxidative catalytic activity in a new halo‐tolerant alcohol dehydrogenase
  ChemCatChem 2020 DOI: 10.1002/cctc.202001112
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• Detecting the nature and solving the crystal structure of a contaminant protein from an opportunistic pathogen
  Acta Crystallographica Section F Structural Biology Communications 2020 DOI: 10.1107/S2053230X20010626
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• Straightforward Background Depletion Unlocks Transaminase Evolution Through Solid-Phase Screening
  2019 DOI: 10.26434/chemrxiv.7874453
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• Straightforward Background Depletion Unlocks Transaminase Evolution Through Solid-Phase Screening
  2019 DOI: 10.26434/chemrxiv.7874453.v1
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• Widely applicable background depletion step enables transaminase evolution through solid-phase screening
  Chemical Science 2019 DOI: 10.1039/C8SC05712E
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• Strategic single point mutation yields a solvent- and salt-stable transaminase from Virgibacillus sp. in soluble form
  Scientific Reports 2018 DOI: 10.1038/s41598-018-34434-3
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• BPSL1626: Reverse and Structural Vaccinology Reveal a Novel Candidate for Vaccine Design against Burkholderia pseudomallei
  Antibodies 2018 DOI: 10.3390/antib7030026
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• A stereospecific carboxyl esterase from Bacillus coagulans hosting nonlipase activity within a lipase-like fold
  FEBS Journal 2018 DOI: 10.1111/febs.14368
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• Boosting of post-exposure human T-cell and B-cell recall responses in vivo by Burkholderia pseudomallei-related proteins
  Immunology 2017 DOI: 10.1111/imm.12709
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• Cellulose production is coupled to sensing of the pyrimidine biosynthetic pathway via c-di-GMP production by the DgcQ protein of Escherichia coli
  Environmental Microbiology 2017 DOI: 10.1111/1462-2920.13918
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• Designing Probes for Immunodiagnostics: Structural Insights into an Epitope Targeting Burkholderia Infections
  ACS Infectious Diseases 2017 DOI: 10.1021/acsinfecdis.7b00080
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• Infection with Burkholderia pseudomallei-immune correlates of survival in acute melioidosis
  Scientific Reports 2017 DOI: 10.1038/s41598-017-12331-5
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• Structural Vaccinology for Melioidosis Vaccine Design and Immunodiagnostics
  Current Tropical Medicine Reports 2017 DOI: 10.1007/s40475-017-0117-3
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