Dr. Ruma sarkar

About

Dr. Ruma Sarkar is an Assistant Professor at B. D. Patel Institute of Allied and Healthcare Sciences, Charotar University of Science and Technology (CHARUSAT), India. Dr. Ruma Sarkar's research focuses on cancer biology and anticancer drug discovery, with particular emphasis on the discovery, mechanistic characterization, and biological evaluation of natural product-derived therapeutics, including phytochemicals, probiotics, postbiotics, and microbial metabolite-derived therapeutics, as well as chemically synthesized anticancer compounds for cancer management. Her research integrates molecular oncology, computational biology, and multi-omics approaches to identify novel therapeutic targets, elucidate molecular mechanisms underlying anticancer activity, and discover biomarkers associated with therapeutic response. Her research interests encompass molecular target-based anticancer drug discovery, including the modulation of heat shock proteins (HSP90), thioredoxin reductase 1 (TrxR1), histone deacetylases (HDACs), the Nrf2/ARE signaling pathway, and oxidative stress/ROS-mediated signaling. She has a particular interest in combination cancer therapy and synergistic therapeutic strategies that enhance treatment efficacy, overcome therapeutic resistance, and improve the therapeutic potential of conventional chemotherapeutic agents. Her research further explores cancer–microbiome interactions, microbe-derived bioactive compounds, cancer signaling pathways, network pharmacology, molecular docking, and experimental validation of novel anticancer agents. She is particularly interested in integrating in silico, in vitro, and experimental approaches to accelerate the discovery and biological validation of innovative anticancer therapeutics. Presently, she is guiding 5 PhD students and has guided the research work of 12 postgraduate dissertation students at BDIAS, CHARUSAT.

Employment

• Charotar University of Science and Technology Assistant Professor
  2022 - Present
• ICFAI University Tripura Assistant Professor
  2020 - 2021
• Vijaygarh Jyotish Ray College (affiliated to University of Calcutta) Visiting Professor
  2019 - 2020
• Sarada Ma Girls College (affiliated to West Bengal State University Assistant Professor
  2016 - 2018

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (35)

• Anticancer potential of 1,2,3-triazole-tethered isonicotinate hybrids: Synthesis, in-silico studies, in-vitro studies and MD simulation
  Journal of Molecular Structure 2026 DOI: 10.1016/j.molstruc.2025.143779
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• Investigation of novel 4-substituted piperazine–pyrrolo[2,3-d]pyrimidine N-phenylacetamides as MELK-targeted anticancer agents for breast cancer therapy
  Bioorganic Chemistry 2026 DOI: 10.1016/j.bioorg.2026.110255
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• Exploring Bakuchiol as an HSP90-Targeting Lead Against Triple-Negative Breast Cancer: Evidence from In Silico, In Vitro, and Synergy Studies
  JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 2026 DOI: 10.1007/S10822-026-00851-0
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• Deciphering the Anticancer Potential of Bifidobacterium longum MB BBLM15 Derived Postbiotic Metabolites in Cervical Cancer: In Vitro, In Silico, and Synergy Studies
  Probiotics and Antimicrobial Proteins 2026 DOI: 10.1007/s12602-026-11120-9
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• Green Synthesis of Pyrazole Linked Thiazole Derivatives With Enhanced Anti‐Breast Cancer Activity: Water Extract of Banana Peel‐Mediated Protocol, Anticancer Screening, Epidermal Growth Factor Receptor Inhibition, In Silico Absorption–Distribution–Metabo…
  Chemistry & Biodiversity 2025 DOI: 10.1002/cbdv.202402791
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• Investigating the role of natural flavonoids in VEGFR inhibition: Molecular modelling and biological activity in A549 lung cancer cells
  JOURNAL OF MOLECULAR STRUCTURE 2025 DOI: 10.1016/J.MOLSTRUC.2024.140392
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• Novel quinolinyl-thiazole hybrid candidates bearing N-methyl piperazine as potential anti-breast cancer agents: synthesis, biological evaluation and computational studies
  RSC ADVANCES 2025 DOI: 10.1039/D5RA06350G
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• PEG-400 Mediated Synthesis of Benzo[d]Imidazo[2,1-b]Thiazoles as Bioactive Scaffolds: Antibreast Cancer Potential, EGFR Inhibition, Antioxidant Study, Molecular Docking, and DFT Insights
  CHEMISTRYSELECT 2025 DOI: 10.1002/SLCT.202500521
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• Polysaccharide-based oral delivery systems for probiotics
  Advances in Probiotic Delivery Systems Strategies for Enhanced Viability Targeted Delivery and Efficacy 2025 DOI: 10.1016/B978-0-443-27594-4.00020-6
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• Role of human microbiota in facilitating the metastatic journey of cancer cells
  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 2025 DOI: 10.1007/S00210-025-03957-8
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