Dr. Esha Sarkar

About

A dynamic and passionate early-career Cancer Biologist, exploring the intricate molecular mechanisms underlying cancer progression, cellular signaling, in vitro toxicology, and cytogenetics. My doctoral research made significant strides in exploring the complex relationship between apoptosis and autophagy, with a particular focus on the roles of reactive oxygen species (ROS). Through this work, I introduced combinatorial therapy using nutraceuticals and repurposed drugs, which significantly inhibited metastatic breast cancer cell survival at the transcriptomic level, offering exciting new possibilities for therapeutic interventions.

Employment

• Government Medical College and Hospital Jalaun (Orai) Tutor lecturer
  2023 - 2024
• Era's Lucknow Medical College and Hospital Research Assistant
  2021 - 2023
• Mahatma Gandhi Institute of Medical Sciences Tutor lecturer
  2018 - 2019

Education

• Sikkim Manipal Institute of Medical Sciences M.Sc in Medical Biochemistry
  2015 - 2018

Projects & Funding

Projects & funding information is unavailable.

Publications (12)

• Curcumin chemo-sensitizes intrinsic apoptosis through ROS-mediated mitochondrial hyperpolarization and DNA damage in breast cancer cells
  Cellular Signalling 2025 23 citations DOI: 10.1016/j.cellsig.2025.111637
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• Synergistic Anticancer Efficacy of Curcumin and Doxorubicin Combination Treatment Inducing S-phase Cell Cycle Arrest in Triple-Negative Breast Cancer Cells: An In Vitro Study
  Cureus 2024 8 citations DOI: 10.7759/cureus.75047
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• The combination of Curcumin and Doxorubicin on targeting PI3K/AKT/mTOR signaling pathway: an in vitro and molecular docking study for inhibiting the survival of MDA-MB-231
  In Silico Pharmacology 2024 11 citations DOI: 10.1007/s40203-024-00231-2
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• Immune response and biochemical connection in diabetes mellitus
  Biochemical Immunology of Diabetes and Associated Complications 2024 0 citations DOI: 10.1016/b978-0-443-13195-0.00006-5
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• Role of symbiotics in the treatment of diabetes mellitus via modification of the immune system
  Biochemical Immunology of Diabetes and Associated Complications 2024 1 citation DOI: 10.1016/b978-0-443-13195-0.00014-4
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• PROSTATE CANCER AND DIABETES: BIOLOGY OR DETECTION BIAS?
  Era's Journal of Medical Research 2022 1 citation DOI: 10.24041/ejmr2022.36
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• In vitro Effect of Chloroquine and Picrolive on DNA Content and Protein-turnover in Liver and Spleen Cultures After Plasmodium Berghei Infection
  Science Publishing Group 2022
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• CRISPR/Cas9 encouraged CAR-T cell immunotherapy reporting efficient and safe clinical results towards cancer
  Cancer Treatment and Research Communications 2022 26 citations DOI: 10.1016/j.ctarc.2022.100641
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• Restoration of Chemoresistance Mechanism by Novel Drug Therapies in Breast Cancer Cell Lines
  Current Drug Therapy 2021 1 citation DOI: 10.2174/1574885516666210525121057
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• Erratic journey of CRISPR/Cas9 in oncology from bench-work to successful-clinical therapy
  Cancer Treatment and Research Communications 2021 15 citations DOI: 10.1016/j.ctarc.2020.100289
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