Basavraj Khanppnavar

About

Biochemist and interested in understanding the molecular mechanisms of membrane proteins involved in transmembrane signaling and host-pathogen interactions. My research integrates biochemistry, structural biology, and functional studies to unravel complex cellular signaling pathways and their modulation by biological toxins. By advancing our understanding of these systems, I aim to tackle key challenges in cell biology and contribute to the development of toxin-inspired tools for therapeutic and biotechnological applications.

Employment

• Paul Scherrer Institute Staff Scientist / Engineer
  2023 - Present
• ETH Zurich Postdoctoral Fellow
  2019 - 2023
• Indian Institute of Chemical Biology Senior Research Fellow
  2016 - 2019
• Indian Institute of Chemical Biology Junior Research Fellow
  2014 - 2016

Education

• Academy of Scientific and Innovative Research Doctorate of Philosophy
  2014 - 2019
• Tezpur University Masters in Molecular Biology and Biotechnology
  2011 - 2013
• Goa University Bachelor of Science in Biotechnology
  2008 - 2011

Projects & Funding

Projects & funding information is unavailable.

Publications (26)

• Neuronal calcium sensors emerge as novel adenylyl cyclase 8 regulators
  2026 DOI: 10.64898/2026.04.19.719435
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• Envisaging the Molecular Foot Printing of Anti-Protozoal Drug Emetine Binding to Lysozyme by Confocal Raman Scattering and X-ray Crystallography
  The Journal of Physical Chemistry B 2026 DOI: 10.1021/acs.jpcb.5c07874
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• Cryo-EM structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation
  Nature Communications 2025 DOI: 10.1038/s41467-025-56304-z
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• Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase
  Nature Chemistry 2024 DOI: 10.1038/s41557-024-01523-y
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• Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor
  Cell 2024 DOI: 10.1016/j.cell.2024.07.005
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• Structural basis of activation and inhibition of Calcium/Calmodulin sensitive membrane adenylyl cyclase 8
  Gordon Research Conference - Calcium Signaling 2024
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• Structural basis of connexin-36 gap junction channel inhibition
  Cell Discovery 2024 DOI: 10.1101/2023.12.09.570920
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• Systematic identification of structure-specific protein–protein interactions
  Molecular Systems Biology 2024 DOI: 10.1101/2023.02.01.522707
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• Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics
  EMBO Reports 2024 DOI: 10.1038/s44319-024-00076-y
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• Advances, challenges, and opportunities in structural biology
  Trends in Biochemical Sciences 2024 DOI: 10.1016/j.tibs.2023.12.006
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