Bikash Chandra Jena
University of Virginia, Purdue University West Lafayette, Indian Institute of Technology Kharagpur
Research areas: Medicine · Oncology · Cancer Cells and Metastasis · Nanoparticle-Based Drug Delivery · TGF-β signaling in diseases
0000-0002-6672-9254
About
I am currently working as a Postdoctoral Research Associate in the Department of Biochemistry and Molecular Genetics at the University of Virginia, where my research focuses on understanding therapeutic resistance in breast cancer and chronic myelomonocytic leukemia (CMML). I employ advanced molecular and cellular biology approaches to dissect drug resistance mechanisms and identify novel therapeutic targets, using both breast cancer-resistant models and CMML patient-derived systems.
Previously, I served as a Postdoctoral Research Associate at Purdue University, West Lafayette, USA, in the Department of Medicinal Chemistry and Molecular Pharmacology. My work there integrated molecular biology, biochemistry, and pharmacology to study the signaling mechanisms of G-protein coupled receptors (GPCRs) and the regulation of adenylyl cyclases.
I earned my Ph.D. in Cancer Biology from the Indian Institute of Technology (IIT) Kharagpur, India. My doctoral research focused on the tumor–stroma interaction and its contribution to chemoresistance in breast cancer. I elucidated the critical role of TGF-β signaling in driving cancer-associated fibroblast (CAF) phenotypes, enhancing chemoresistance via activation of the p44/42 MAPK pathway, and promoting epithelial-to-mesenchymal transition (EMT) in non-transformed fibroblasts. I also explored the impact of TGF-β on tumor metabolism through induction of autophagy and MCT4-mediated lactate export in CAFs. Additionally, I investigated the role of tumor-derived exosomes in mediating CAF activation and drug resistance.
Employment
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University of Virginia Postdoctoral Research Associate2023 - Present
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Purdue University West Lafayette Post Doctoral Research Associate2022 - 2023
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Indian Institute of Technology Kharagpur Ph.D. Research Scholar2014 - 2022
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (28)
- Redox‐Responsive Core Cross‐Linked Micelle as Anticancer Drug Delivery Vehicle Save
- PSMC2 promotes resistance against temozolomide in glioblastoma via suppressing JNK-mediated autophagic cell death Save
- Biochemical pharmacology of adenylyl cyclases in cancer Save
- A novel computational predictive biological approach distinguishes Integrin β1 as a salient biomarker for breast cancer chemoresistance Save
- A two-photon responsive hydroxyphenylquinazolinone (HPQ)-based fluorescent organic nanoprodrug for H2S release against oxidative stress Save
- TGF-β1 induced autophagy in cancer associated fibroblasts during hypoxia contributes EMT and glycolysis via MCT4 upregulation Save
- Understanding the function and regulation of Sox2 for its therapeutic potential in breast cancer Save
- Screening of the Prime bioactive compounds from Aloe vera as potential anti-proliferative agents targeting DNA Save
- Active autophagy in cancer‐associated fibroblasts: Recent advances in understanding the novel mechanism of tumor progression and therapeutic response Save
- The transformation of cancer-associated fibroblasts: Current perspectives on the role of TGF-β in CAF mediated tumor progression and therapeutic resistance Save
- Synthesis, self-assembly and drug release study of a new dual-responsive biocompatible block copolymer containing phenylalanine derivative Save
- Paracrine TGF-β1 from breast cancer contributes to chemoresistance in cancer associated fibroblasts via upregulation of the p44/42 MAPK signaling pathway Save
- The emerging roles of exosomes in anti-cancer drug resistance and tumor progression: An insight towards tumor-microenvironment interaction. Save
- Cancer associated fibroblast mediated chemoresistance: A paradigm shift in understanding the mechanism of tumor progression. Save
- Causes of cancer: physical, chemical, biological carcinogens, and viruses Save
- The Interplay of Autophagy and the Immune System in the Tumor Microenvironment Save
- Abstract 120: Paracrine TGF-β1 induces tamoxifen resistance in cancer-associated fibroblsts by activation of p44/42 MAPK signaling pathway Save
- Abstract 3638: Combination of metformin and metronomic liposomal doxorubicin exerts a robust anticancer effect in triple negative breast cancer by inhibiting breast cancer stem cells & the Wnt/beta-catenin pathway Save
- A copper-free click reaction for the synthesis of redox-responsive water-soluble core cross-linked nanoparticles for drug delivery in cancer therapy Save
- Exosome as a Novel Shuttle for Delivery of Therapeutics across Biological Barriers Save