Prasant Kumar Jena
Cedars Sinai Health Sciences University, University of California, Davis, Nirma University
Research areas: Medicine · Oncology · Gut microbiota and health · Probiotics and Fermented Foods · Drug Transport and Resistance Mechanisms
0000-0002-6729-5881
About
I have more than 10 years of research experience in studying the impact of diet and gut microbiota on the development of metabolic diseases including obesity, diabetes, and carcinogenesis. In my graduate studies, I developed a high fructose- and sucrose-induced diabetes rat model to study the effect of microbiota and probiotic intervention in lipid and carbohydrate metabolism. Through this project, I identified several probiotic bacteria and antimicrobial peptides that can be used for prevention and treatment of diabetes and aquaculture infectious disease. At University of California, Davis, I started studying the effect of Western diet through bile acid signaling pathways that lead to the development of non-alcoholic steatohepatitis. Thus far, our published data clearly show dysregulated bile acid synthesis drives gut dysbiosis, which causes hepatic inflammation. In addition, Western diet intake lead to systemic inflammation including reduced neuroplasticity, dermatitis, fatty liver, etc. Currently at Cedars Sinai Medical Center, I am working on the effect of bile acid signaling pathways and host microbe interaction in development of cardiovascular disease (Atherosclerosis and Kawasaki disease).
Employment
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Cedars Sinai Health Sciences University Project Scientist2019 - Present
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University of California Davis Postdoctoral Scholar2014 - 2019
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Nirma University PhD Scholar2009 - 2014
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Vikram A Sarabhai Community Science Centre Science Educator2008 - 2009
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VASCSC (Ahmedabad), DST (Govt. of India), Max Planck Society (Germany) Science Communicator2007 - 2008
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (36)
- Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Mitophagy Save
- Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vasculitis in Mice Save
- Gut Microbiota Alterations in Patients With Kawasaki Disease Save
- Intestinal Microbiota Remodeling Protects Mice from Western Diet-Induced Brain Inflammation and Cognitive Decline Save
- Short-Term Exposure to a Western Diet Induces Psoriasiform Dermatitis by Promoting Accumulation of IL-17A–Producing γδ T Cells Save
- Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation Save
- Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment Save
- Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation Save
- Preparation and optimization of moxifloxacin microspheres for colon targeted delivery using quality by design approach: in vitro and in vivo study. Save
- Influence of Gut Microbiota on Inflammation and Pathogenesis of Sugar Rich Diet Induced Diabetes Save
- Purification and Molecular Characterization of the Novel Highly Potent Bacteriocin TSU4 Produced by Lactobacillus animalis TSU4. Save
- Co-activator binding protein PIMT mediates TNF-α induced insulin resistance in skeletal muscle via the transcriptional down-regulation of MEF2A and GLUT4. Save
- In Vitro Evaluation of Probiotic Properties of Lactic Acid Bacteria from the Gut of Labeo rohita and Catla catla Save
- Investigation of Chitosan for Prevention of Diabetic Progression Through Gut Microbiota Alteration in Sugar Rich Diet Induced Diabetic Rats. Save
- Understanding the role of heat shock protein isoforms in male fertility, aging and apoptosis. Save
- Determining the reversible potentials of hydro alcoholic extracts of Eclipta alba in boric acid induced male accessory reproductive organ toxicity Save
- Colicin E2 Expression in Lactobacillus brevis DT24, A Vaginal Probiotic Isolate, against Uropathogenic Escherichia coli Save
- Bacteriocins and their applications for the treatment of bacterial diseases in aquaculture: A review Save
- Effects of dietary supplementation of potential probiotic Bacillus subtilis VSG1 singularly or in combination with Lactobacillus plantarum VSG3 or/and Pseudomonas aeruginosa VSG2 on the growth, immunity and disease resistance of Labeo rohita Save
- Impact of targeted specific antibiotic delivery for gut microbiota modulation on high-fructose-fed rats Save