Vijay Pratap Singh

About

My broad interest is to understand the role of genome maintenance in the cells of the developing placenta and its impact on placental development. The placenta is an essential organ in eutherian mammals and acts as an interface between the fetus and mother. My laboratory will use the diverse molecular, cellular, genetic, and proteomics tools available in M. musculus and human cells to identify the regulators of genome maintenance in different placental cell types. My central hypothesis is that placental physiology relies on the regulation of genome maintenance, with increased genomic instability driving cellular senescence that impacts placental aging, parturition, and embryo development. My research program has immediate implications for maternal-fetal health but may also have broader implications for understanding fundamental molecular ties between genome maintenance and signaling that underlie cancer and aging.

Employment

• National Institute for Research in Tribal Health Scientist /DBT-Ramalingaswami Fellow
  2023 - Present
• Stowers Institute for Medical Research Post Doc Fellow
  2014 - 2023

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (21)

• Monitoring Rubella Immunity and Transmission in Central India Amidst Elimination Efforts
  Microbiology and Immunology 2026 DOI: 10.1111/1348-0421.70065
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• Genomics and Transcriptomics in Reproductive Health
  2024 DOI: 10.1201/9781003487548-3
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• Personalized Medicine in Reproductive Health
  2024 DOI: 10.1201/9781003487548-7
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• Linking DNA damage and senescence to gestation period and lifespan in placental mammals
  Frontiers in Cell and Developmental Biology 2024 DOI: 10.3389/fcell.2024.1480695
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• Myc promotes polyploidy in murine trophoblast cells and suppresses senescence
  Development 2023 DOI: 10.1242/dev.201581
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• Maternal Smc3 protects the integrity of the zygotic genome through DNA replication and mitosis
  Development 2021 DOI: 10.1242/dev.199800
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• PCR amplicons identify widespread copy number variation in human centromeric arrays and instability in cancer
  Cell Genomics 2021 DOI: 10.1016/j.xgen.2021.100064
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• Immature Follicular Origins and Disrupted Oocyte Growth Pathways Contribute to Decreased Gamete Quality During Reproductive Juvenescence in Mice
  Frontiers in Cell and Developmental Biology 2021 DOI: 10.3389/fcell.2021.693742
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• Protocol for mouse trophoblast stem cell isolation, differentiation, and cytokine detection
  STAR Protocols 2021 DOI: 10.1016/j.xpro.2020.100242
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• Maternal Smc3 Protects the Integrity of the Zygotic Genome Through DNA Replication and Mitosis
  SSRN Electronic Journal 2020 DOI: 10.2139/ssrn.3689888
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