Carien Creutzberg
Leiden University Medical Center, Erasmus University Rotterdam, Erasmus MC Cancer Institute, Leiden University
Research areas: Medicine · Obstetrics and Gynecology · Endometrial and Cervical Cancer Treatments · Breast Cancer Treatment Studies · Ovarian cancer diagnosis and treatment
0000-0002-7008-4321
About
Carien Creutzberg is Professor of Radiation Oncology, specialised in Radiation Therapy for Gynecological Cancers, at the Department of Radiation Oncology at Leiden University Medical Center, the Netherlands. She has completed clinical training in Radiation Oncology at the Daniel den Hoed Cancer Center in Rotterdam in 1993, and has defended her PhD thesis at the Erasmus University Rotterdam in 1998. She started as associate professor at Leiden University Medical Centre in 2000, and continued to combine patient care with clinical research and teaching of students and residents. She was appointed full professor as of August 2012. Her scientific and educational activities are consistent with her specialisation in Gynecologic Oncology. She has been initiator and principal investigator of the PORTEC-1 (1990-97), PORTEC-2 (2002-06), PORTEC-3 (2006-2013) and PORTEC-4 (ongoing) trials, and has been awarded Dutch Cancer Society Grants for all of the PORTEC trials, a translational research project and two patient rehabilitation projects. She has been one of the initiators of the Dutch Gynecologic Oncology Group, of which she is board member. She has been Council member of the European Society of Gynaecological Oncology from 2013-2017, and is currently co-chair of the GCIG Endometrial Cancer Committee, ESMO Faculty Member for the Gynaecological Cancer Track and member of the Dutch Cancer Society Scientific Board. She has been member of the Uterine Corpus Cancer Task Force of the National Cancer Institute USA (2007-2013), Council member of the International Gynecologic Cancer Society (2008-2012), and Senior Editor of Int J Gynecol Cancer. She has been supervising PhD theses on clinical and translational research based on the PORTEC-trials and related studies since 2008. She has been invited speaker at numerous national and international scientific meetings on Gynecologic Oncology and Radiation Oncology, and has written over 120 scientific articles, book chapters and commentaries. Her research in radiation therapy for endometrial cancer has had clear impact on treatment guidelines and research programs for Endometrial Cancer worldwide
Employment
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Leiden University Medical Center Professor of Radiation Oncology
Education
- 1992 - 1998
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Erasmus MC Kanker Instituut Radiation Oncologist1988 - 1993
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Leiden University M.D.1979 - 1987
Projects & Funding
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Reducing the greatest uncertainty in radiotherapy. National Health and Medical Research Council2016 - 2018
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Chemoradiation and adjuvant chemotherapy versus radiation alone in high risk and advanced endometrial cancer National Health and Medical Research Council2009 - 2012
Publications (177)
- FIGO staging of endometrial cancer: 2023 Save
- Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry Save
- Microcystic elongated and fragmented (MELF) pattern of invasion: Molecular features and prognostic significance in the PORTEC-1 and -2 trials. Save
- Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Save
- p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial. Save
- Efficacy and safety of durvalumab with olaparib in metastatic or recurrent endometrial cancer (phase II DOMEC trial). Save
- Special Issue: Radiation Oncology in Gynecologic Malignancies. Save
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients. Save
- Vaginal brachytherapy management of stage I and II endometrial cancer. Save
- Prognostic relevance of the molecular classification in high-grade endometrial cancer for patients staged by lymphadenectomy and without adjuvant treatment. Save
- A sexual rehabilitation intervention for women with gynaecological cancer receiving radiotherapy (SPARC study): design of a multicentre randomized controlled trial. Save
- Radiotherapy Quality Assurance in the PORTEC-3 (TROG 08.04) Trial. Save
- Cancer of the corpus uteri: 2021 update. Save
- PROTECT: Prospective Phase-II-Trial Evaluating Adaptive Proton Therapy for Cervical Cancer to Reduce the Impact on Morbidity and the Immune System Save
- Radiation Therapy Techniques and Treatment-Related Toxicity in the PORTEC-3 Trial: Comparison of 3-Dimensional Conformal Radiation Therapy Versus Intensity-Modulated Radiation Therapy. Save
- Radiotherapy Versus Inguinofemoral Lymphadenectomy as Treatment for Vulvar Cancer Patients With Micrometastases in the Sentinel Node: Results of GROINSS-V II. Save
- Substantial Lymphovascular Space Invasion Is an Adverse Prognostic Factor in High-risk Endometrial Cancer. Save
- Defining Substantial Lymphovascular Space Invasion in Endometrial Cancer. Save
- Phase II study of definitive chemoradiation for locally advanced squamous cell cancer of the vulva: An efficacy study. Save
- Psychometric validation of the European Organisation for Research and Treatment of Cancer-Quality of Life Questionnaire Sexual Health (EORTC QLQ-SH22). Save