Saubhik Som

About

Dr. Saubhik Som completed his Ph.D. with Prof. Sandeep Eswarappa in the Dept of Biochemistry, Indian Institute of Science, Bengaluru, India. His PhD project focused on the physiological significance of stop codon readthrough in a mitochondrial membrane protein MTCH2. He studied a MTCH2 readthrough-deficient 3′UTR knockout transgenic mouse and showed that MTCH2 readthrough is important in maintaining MTCH2 protein levels, and the deletion results in reduced skeletal muscle ATP levels, oxidative phosphorylation and musculoskeletal activity in mice, due to altered mitochondrial translation. This work supports the hypothesis that stop codon readthrough has evolved as a biologically meaningful mechanism that can quickly fine-tune protein levels and cellular physiology in a tissue-dependent manner (Som et al., manuscript under preparation).
During his PhD, he also developed a rapid in vivo assay that uses subcutaneous injection of plasmid DNA into the mouse tail to study post-transcriptional gene regulation and can be used for in vivo screening of therapeutics (Som et al., FEBS Letters, 2025).

Employment

• Indian Institute of Science Bangalore Postdoctoral Research Fellow
  2025 - 2026

Education

• Indian Institute of Science Bangalore Integrated MS-PhD in Biological Science
  2017 - 2025
• Presidency University B.Sc (H) in Life Science
  2014 - 2017

Projects & Funding

Projects & funding information is unavailable.

Publications (7)

• Process of inducing translational readthrough across pre-mature stop codon
  2026
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• Translation of a four-codon ORF in the 3′UTR of MAP3K10 regulates its expression
  2026 DOI: 10.64898/2026.04.27.721023
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• A compact, portable degron tool derived from the 3′UTR of MTCH2 for tunable degradation of proteins
  2026 DOI: 10.64898/2026.02.04.703731
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• A rapid in vivo assay to study the regulation of gene expression
  FEBS Letters 2025 DOI: 10.1002/1873-3468.70096
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• Kinetics of Translating Ribosomes Determine the Efficiency of Programmed Stop Codon Readthrough
  Journal of Molecular Biology 2023 DOI: 10.1016/j.jmb.2023.168274
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• Identification and functional characterization of mRNAs that exhibit stop codon readthrough in Arabidopsis thaliana.
  The Journal of biological chemistry 2022 DOI: 10.1016/j.jbc.2022.102173
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• Mammalian proteome expansion by stop codon readthrough.
  Wiley interdisciplinary reviews. RNA 2022 DOI: 10.1002/wrna.1739
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