0000-0002-7139-9683 About
I have been working in the field of matrix biology for most of my life, and i study the regulation of cellular proteases, mainly matrix metalloproteases. My main research focuses on elucidating the role of MMPs, and the crosstalk with growth factors, receptors, and cell adhesion molecules in cancers, alcohol-induced liver damage, diabetes and endometriosis, Idiopathic pulmonary fibrosis (IPF), attenuating brain stroke and gastric ulcers induced by stress, alcohol, non-steroidal anti-inflammatory drug, and infection by Helicobacter pylori; effects of potential mediators like cytokines, growth factors and transcription factors for H. pylori infection. I also work on understanding the biochemistry behind the mechanism of wound healing, gastric inflammation, gastric ulcers, cancers and the effect of free as well as encapsulated lead bioactive molecules viz. curcumin, melatonin, and antioxidants etc. on them in regard to angiogenesis, collagen synthesis, apoptosis and regulation of MMPs. Additionally, I also investigate the role of single nucleotide polymorphims in promoter regions of MMPs and their associations with the risk of gastric cancer, ovarian cancer, endometriosis, etc.
Employment
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Indian Institute of Chemical Biology CSIR Senior Principal Scientist and HOD2002 - Present
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (41)
- CRISPR detectives against SARS-CoV-2: a major setback against COVID-19 blowout. Save
- Insights Into the Regulation of Gynecological Inflammation-Mediated Malignancy by Metalloproteinases Save
- Modification of Cas9, gRNA and PAM: Key to further regulate genome editing and its applications. Save
- Understanding the immunological aspects of SARS-CoV-2 causing COVID-19 pandemic: A therapeutic approach Save
- Expression of matrix metalloproteinase-9 in gingival tissue biopsy in patients with slowly/ moderately and rapidly progressing periodontitis: An observational study. Save
- A bis-indole/carbazole based C5-curcuminoid fluorescent probe with large Stokes shift for selective detection of biothiols and application to live cell imaging. Save
- A Common Tag Nucleotide Variant in MMP7 Promoter Increases Risk for Hypertension via Enhanced Interactions With CREB (Cyclic AMP Response Element-Binding Protein) Transcription Factor. Save
- Neuro-protective role of nanocapsulated curcumin against cerebral ischemia-reperfusion induced oxidative injury. Save
- Triumph and tumult of matrix metalloproteinases and their crosstalk with eicosanoids in cancer. Save
- Protective Role of Black Tea Flavonoids Against Ethanol-Induced Gastropathy via Matrix Metalloproteinase Pathway. Save