Vijay K. Nuthakki

About

Motivated and innovative medicinal chemist with demonstrated research experience in medicinal chemistry, especially natural product-driven drug discovery for Alzheimer's disease and cancer. Worked on projects like IND filing of anticancer lead IIIM-290, Phytopharmaceutical mission, drug re-purposing and further medicinal chemistry for SARS-CoV-2 at CSIR-IIIM, Jammu. Worked on the design and synthesis of TRPM8 inhibitors for the treatment of cold mediated pain at the School of Pharmacy, University of Pittsburgh. Currently working as an Assistant professor at the GITAM School of Pharmacy, Hyderabad.

Research interests: Drug discovery for Alzheimer's disease and cancer via medicinal chemistry, natural products chemistry, and computational chemistry.

Employment

• GITAM School of Pharmacy Assistant Professor
  2024 - Present
• University of Pittsburgh School of Pharmacy Postdoctoral Associate
  2022 - Present
• Council of Scientific & Industrial Research Indian Institute of Integrative Medicine Project Assistant
  2016 - 2022
• SRK Foundation Assistant Professor
  2015 - 2016
• Karnataka Antibiotics and Pharmaceuticals Ltd Management Trainee
  2012 - 2012

Education

• Academy of Scientific and Innovative Research PhD
  2019 - 2022
• Hindu College of Pharmacy Master of Pharmacy
  2012 - 2014
• SRM College of Pharmacy Bachelor of pharmacy
  2007 - 2011

Projects & Funding

Projects & funding information is unavailable.

Publications (16)

• Synthesis and Biological Evaluation of Colchicine─Aryl/Alkyl Amine Hybrids as Potential Noncytotoxic Cholinesterase Inhibitors: Identification of SBN-284 as a Dual Inhibitor of Cholinesterases and NLRP3 Inflammasome
  ACS Chemical Neuroscience 2024 DOI: 10.1021/acschemneuro.4c00153
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• Methoxy-naphthyl-Linked N‑Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure–Activity Relationship
  ACS Omega 2023 DOI: 10.1021/acsomega.2c08167
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• Design, Synthesis, and Pharmacological Evaluation of Embelin–Aryl/alkyl Amine Hybrids as Orally Bioavailable Blood–Brain Barrier Permeable Multitargeted Agents with Therapeutic Potential in Alzheimer’s Disease: Discovery of SB-1448
  ACS Chemical Neuroscience 2023 DOI: 10.1021/acschemneuro.3c00030
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• Blood–brain barrier permeable benzylpiperidin‐4‐yl‐linked benzylamino benzamides as dual cholinesterase inhibitors
  Drug Development Research 2022 DOI: 10.1002/ddr.21997
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• A Coumarin−Donepezil Hybrid as a Blood−Brain Barrier Permeable Dual Cholinesterase Inhibitor: Isolation, Synthetic Modifications, and Biological Evaluation of Natural Coumarins
  ChemMedChem 2022 DOI: 10.1002/cmdc.202200300
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• Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids
  European Journal of Medicinal Chemistry 2022 DOI: 10.1016/j.ejmech.2021.113938
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• Identification of plant-based multitargeted leads for Alzheimer's disease: In-vitro and in-vivo validation of Woodfordia fruticosa (L.) Kurz
  Phytomedicine 2021 DOI: 10.1016/j.phymed.2021.153659
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• Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors
  PLOS Pathogens 2021 DOI: 10.1371/journal.ppat.1009706
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• Identification of aplysinopsin as a blood-brain barrier permeable scaffold for anti-cholinesterase and anti-BACE-1 activity
  Bioorganic Chemistry 2021 DOI: 10.1016/j.bioorg.2020.104568
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• Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase
  European Journal of Medicinal Chemistry 2020 DOI: 10.1016/j.ejmech.2020.112761
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