SA
SAIMA AIJAZ
Jawaharlal Nehru University, University College London, Indian Institute of Science
0000-0002-7512-9859
About
The main focus of my laboratory is to investigate the mechanisms that regulate the disruption of epithelial tight junctions in various disease contexts. We are using a variety of approaches to examine the pathways associated with the break-down of tight junctions. The overall objective is to devise strategies that can prevent or reverse the leakage through tight junctions in disease conditions.
Employment
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Jawaharlal Nehru University Assistant Professor
Education
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University College London Post-doctoral fellowship2000 - 2006
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Indian Institute of Science PhD
Projects & Funding
Projects & funding information is unavailable.
Publications (27)
- Enteropathogenic E. coli effector Map interacts with Rab13 and regulates the depletion of the tight junction proteins occludin and claudins via cathepsin B-mediated mechanisms Save
- The C-terminal proline-rich repeats of Enteropathogenic E. coli effector EspF are sufficient for the depletion of tight junction membrane proteins and interactions with early and recycling endosomes Save
- EnteropathogenicE. colieffector Map regulates the depletion of the tight junction proteins occludin and claudin-4 via cathepsin B and Rab13-mediated mechanisms Save
- The C-terminal proline-rich repeats of Enteropathogenic E. coli effector EspF are sufficient for the depletion of tight junction membrane proteins and interactions with early and recycling endosomes Save
- Tracing the origins of the novel corona virus SARS-CoV-2. JNU-ENVIS 25(1): 19-20. Save
- Enteropathogenic E. coli effectors EspF and Map independently disrupt tight junctions through distinct mechanisms involving transcriptional and post-transcriptional regulation Save
- Transcriptional and post-transcriptional mechanisms are involved in tight junction disruption by Enteropathogenic E. coli effectors EspF and Map Save
- Enteropathogenic E. coli breaking the intestinal tight junction barrier. F1000Research, 4, 231 (2016). Save
- Generation of a MDCK cell line with constitutive expression of the Enteropathogenic E. coli effector protein Map as an in vitro model of pathogenesis. Save
- The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription. Save