SOUMEN BARMAN

About

I am a Postdoctoral Fellow in the Laboratory of Molecular Biology and Immunology at the National Institute of Health (NIH), working on decoding cis-regulatory elements and transcription factor footprints at the IgH locus in B cells. I received my Ph.D. in Biological Sciences from (Indian Institute of Science Education and Research Kolkata) IISER Kolkata, where I studied how BRPF family bromodomains and associated reader modules interpret histone acetylation and contribute to the epigenetic regulation of hepatocellular carcinoma. My training combines molecular biology, protein biochemistry, chromatin immunoprecipitation, and quantitative biophysics with extensive experience in structural modeling, virtual screening, and sequencing data analysis (ChIP-seq, ATAC-seq, bulk and single-cell RNA-seq, proteomics). I am broadly interested in how chromatin readers and cis-regulatory elements integrate signaling cues to control gene expression in normal and malignant cells, and in leveraging this knowledge to identify new therapeutic targets.

Employment

• National Institute on Aging Post Doc
  2024 - 2029
• Indian Institute of Science Education and Research Kolkata Research Scholar
  2019 - 2024

Education

• IISER - Kolkata PhD
  2019 - 2024
• Vidyasagar University MSc
  2016 - 2018
• Vidyasagar University BSc
  2013 - 2018

Projects & Funding

Projects & funding information is unavailable.

Publications (15)

• A Unique Ceruloplasmin Shows Distinct Redox Potentials for the Catalytic and Electron-Transfer Metal Sites
  Peptide Science 2025 DOI: 10.1002/pep2.24387
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• Amyloid β-Peptide Segment Conjugated Side-Chain Proline-Based Polymers as Potent Inhibitors in Lysozyme Amyloidosis
  Bioconjugate Chemistry 2024 DOI: 10.1021/acs.bioconjchem.3c00509
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• Olive phenolic compounds, potent tankyrase 1 inhibitor exhibit anti colon cancer effects by blocking Wnt/β-catenin pathway
  Biorxiv 2024 DOI: 10.1101/2024.05.08.593091
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• Uncovering the non-histone interactome of the BRPF1 bromodomain using site-specific azide-acetyllysine photochemistry
  Journal of Biological Chemistry 2024 DOI: 10.1016/j.jbc.2023.105551
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• Integrated virtual screening and MD simulation approaches toward discovering potential inhibitors for targeting BRPF1 bromodomain in hepatocellular carcinoma
  Journal of Molecular Graphics and Modelling 2023 DOI: 10.1016/j.jmgm.2023.108642
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• Novel insights into the recognition of acetylated histone H4 tail by the TRIM24 PHD-Bromo module
  Biochemical Journal 2023 DOI: 10.1042/bcj20230011
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• Erratum: Novel insights into the recognition of acetylated histone H4 tail by the TRIM24 PHD-Bromo module (Biochemical Journal (2023) 480:9 (629–647) DOI: 10.1042/BCJ20230011)
  Biochemical Journal 2023 DOI: 10.1042/BCJ-2023-0011_COR
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• Insulin Fibril Inhibition Using Glycopolymeric Nanoassemblies
  Biomaterials Science 2023 DOI: 10.1039/d2bm02078e
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• Identification of novel natural product inhibitors of BRD4 using high throughput virtual screening and MD simulation
  Journal of Biomolecular Structure and Dynamics 2022 DOI: 10.1080/07391102.2022.2155346
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• Molecular Insights into the Recognition of Acetylated Histone Modifications by the BRPF2 Bromodomain
  Biochemistry 2022 DOI: 10.1021/acs.biochem.2c00297
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