Vaibhav Kumar Nain

About

As a graduate student at Translational Health Science and Technology Institute (THSTI), I am working in the area of Infectious disease biology. I am interested in mycobacterial physiology, persistence and pathogenicity by identifying and characterizing such genes and/ or physiologically relevant conditions that leads to persisters formation by utilizing several in-vitro, ex-vivo and in-vivo models.

Employment

• Translational Health Science and Technology Institute Project Research Scientist-I
  2024 - Present
• Translational Health Science and Technology Institute ICMR-Senior Research Fellow
  2021 - 2024
• Translational Health Science and Technology Institute ICMR-Junior Research Fellow
  2019 - 2020
• Institute of Genomics and Integrative Biology CSIR Project Fellow
  2018 - 2018

Education

• Translational Health Science and Technology Institute Doctor of Philosophy (Ph. D.)
  2019 - 2024
• University of Delhi - South Campus Master of Science in Biochemistry
  2016 - 2018
• University of Delhi Ram Lal Anand College Bachelor of Science in Microbiology Honours
  2013 - 2016

Projects & Funding

Projects & funding information is unavailable.

Publications (11)

• Orthogonal perturbation of sulfur availability reveals antibiotic-induced synthetic lethality in Mycobacterium tuberculosis
  2026 DOI: 10.64898/2026.07.28.741166
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• Disruption of De Novo Histidine Biosynthesis of Mycobacterium tuberculosis Affects the Depletion of the Pathogen
  ACS Infectious Diseases 2025 DOI: 10.1021/acsinfecdis.5c00393
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• Phosphoglucomutase A-mediated metabolic adaptation is essential for antibiotic and disease persistence in Mycobacterium tuberculosis
  mSystems 2025 DOI: 10.1128/msystems.00420-25
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• A pH-dependent direct sulfhydrylation pathway is required for the pathogenesis of Mycobacterium tuberculosis
  Communications Biology 2025 DOI: 10.1038/s42003-025-08051-6
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• VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection
  Frontiers in Immunology 2024 DOI: 10.3389/fimmu.2024.1302163
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• Rv0495c regulates redox homeostasis in Mycobacterium tuberculosis
  Tuberculosis 2024 DOI: 10.1016/j.tube.2024.102477
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• Biocompatible Human Placental Extracellular Matrix Derived Hydrogels
  Advanced Biology 2024 DOI: 10.1002/adbi.202300349
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• Transcription factor mce3R modulates antibiotics and disease persistence in Mycobacterium tuberculosis
  Research in Microbiology 2023 DOI: 10.1016/j.resmic.2023.104082
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• Antibacterial potential of indigenous plant extracts against multidrug-resistant bacterial strains isolated from New Delhi region
  GSC Biological and Pharmaceutical Sciences 2021 DOI: 10.30574/gscbps.2021.14.2.0053
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• IMPACT OF SANITARY LANDFILLS ON MICROBIOLOGICAL ACTIVITY AND WATER QUALITY INDEX OF GROUNDWATER IN DELHI, INDIA
  Sambodhi 2020
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