Nobuyuki Ishibashi
Boston University, Children’s National Health System, Gunma University School of Medicine, Tokyo Women’s Medical University
0000-0002-7910-4050
About
I joined the faculty of the Boston University Chobanian & Avedisian School of Medicine in March 2025 as a Professor of Anatomy & Neurobiology and also hold a faculty appointment in the Department of Cardiology at Boston Children’s Hospital. Prior to this transition, I spent 19 years at Children’s National Hospital (CNH) in Washington, DC. Since 2010, I served as a Principal Investigator at the Center for Neuroscience Research and Director of the Cardiac Surgery Research Laboratory, while holding the Foglia-Hills Chair for Pediatric Cardiac Research. My clinical training in Surgery, Cardiovascular Surgery, and Pediatric Cardiac Surgery was completed at the Heart Institute of Japan, Tokyo Women’s Medical University, where I earned board certifications from both the Japanese Board of Surgery and the Japanese Board of Cardiovascular Surgery. I further advanced my research expertise through a fellowship at the Center for Neuroscience Research at CNH.
My research investigates the impact of congenital heart disease (CHD) and subsequent cardiac surgery on the developing brain. As Principal Investigator (PI) on multiple NIH- and DoD-funded grants, I have employed advanced neuroscience techniques to explore brain development in clinically relevant animal models, culminating in numerous publications. I pioneered studies elucidating the relationship between the subventricular zone and cortical growth in CHD, earning recognition from both cardiovascular and neuroscience communities, as evidenced by an invited review article. My ultimate goal as a clinician-scientist is to optimize treatment strategies and develop novel therapeutic approaches that mitigate developmental impairments in children with CHD. The translational nature of my research program has led to significant milestones, including the development of the NIH-funded Phase 1 clinical trial (MeDCaP trial, R33HL146394) at CNH. This trial confirmed the safety and feasibility of a cell-based therapeutic approach (NCT04236479), for which I serve as co-PI.
Employment
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Boston University Professor2025 - Present
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Children’s National Health System2006 - 2025
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Tokyo Women’s Medical University1998 - 2006
Education
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Gunma University School of Medicine MD1992 - 1998
Projects & Funding
Projects & funding information is unavailable.
Publications (63)
- Mesenchymal Stromal Cells Improve Postoperative Cardiac Dysmaturation in a Juvenile Porcine Model. Save
- Mesenchymal Stromal Cells Mitigate Prolonged Cardiopulmonary Bypass-Induced Neuroinflammation Save
- Significance of birth in the maintenance of quiescent neural stem cells. Save
- Transformation of radial glia into postnatal neural stem cells depends on birth. Save
- Outer radial glia promotes white matter regeneration after neonatal brain injury. Save
- Ciliopathy interacts with neonatal anesthesia to cause non-apoptotic caspase-mediated motor deficits Save
- The role of primary cilia in congenital heart defect-associated neurological impairments. Save
- Establishing Optimal Control Cohorts for Phase 1 Trials: Retrospective Analysis of Clinical and Biological Outcomes in Neonates and Infants Undergoing Two-Ventricle Repair. Save
- Mesenchymal Stromal Cell Delivery Via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Model. Save
- Trajectories of neurodevelopment and opportunities for intervention across the lifespan in congenital heart disease. Save