Dr. Manish Kumar Thakur

About

As Associate Vice President at GeNei Laboratories, I lead the strategic alignment of R&D and product development with the broader vision of GeNei Bioscience. With over 18 years of experience across industry and academia, I bring deep scientific expertise and a strong track record of delivering innovative solutions in drug discovery and protein science.

My background includes a Ph.D. in Biochemistry and a Postdoc in Structural Biology, with hands-on and leadership experience in:
Protein chemistry, molecular biology, Gene to Protein, Gene to Structure and enzyme kinetics.

Managing cross-functional teams and global client collaborations
I’ve successfully led multiple client-driven projects, optimized resource utilization, and built high-performing scientific teams. My passion lies in translating complex science into impactful products and partnerships that advance human health.

Employment

• Genei Laboratories Pvt Ltd Associate Vice President
  2022 - Present
• Syngene International (India) Senior Reserach Investigator
  2019 - 2022
• Jubilant Biosys Ltd Senior Research Scientist
  2006 - 2018

Education

• Stony Brook University Postdoctoral Research Associate
  2018 - 2019

Projects & Funding

Projects & funding information is unavailable.

Publications (10)

• Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance
  Nature Communications 2022 DOI: 10.1038/s41467-022-34724-5
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• Discovery and molecular basis of subtype-selective cyclophilin inhibitors
  Nature Chemical Biology 2022 DOI: 10.1038/s41589-022-01116-1
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• What Makes a Kinase Promiscuous for Inhibitors?
  Cell Chemical Biology 2019 DOI: 10.1016/j.chembiol.2018.11.005
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• A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
  Scientific Reports 2018 DOI: 10.1038/s41598-018-22081-7
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• Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Å resolution
  Biochemical and Biophysical Research Communications 2017 DOI: 10.1016/j.bbrc.2016.12.030
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• Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide
  Biochemical and Biophysical Research Communications 2017 DOI: 10.1016/j.bbrc.2017.07.087
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• Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 Å resolution
  Biochemical and Biophysical Research Communications 2016 DOI: 10.1016/j.bbrc.2016.07.121
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• The structure of XIAP BIR2: Understanding the selectivity of the BIR domains
  Acta Crystallographica Section D: Biological Crystallography 2013 DOI: 10.1107/S0907444913016284
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• Characterization of the luteinizing hormone beta (LH-β) subunit gene in the Indian river buffalo (Bubalus bubalis)
  General and Comparative Endocrinology 2008 DOI: 10.1016/j.ygcen.2007.03.012
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• Expression stability of two housekeeping genes (18S rRNA and G3PDH) during in vitro maturation of follicular oocytes in buffalo (Bubalus bubalis)
  Animal Reproduction Science 2008 DOI: 10.1016/j.anireprosci.2007.04.012
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