Nithin Sam Ravi

Employment

• University of Pennsylvania Post Doctoral Fellow
  2025 - Present
• Children's Hospital of Philadelphia Post Doctoral Fellow
  2024 - 2025
• Christian Medical College Vellore Centre for Stem Cell Research Senior Research Fellowship
  2017 - 2023
• Christian Medical College & Hospital Research Associate
  2015 - 2017

Education

• Christian Medical College & Hospital PhD
  2017 - 2023
• Dr.M.G.R. Educational and Research Institute M.Tech Medical Biotechnology
  2013 - 2015
• Tamil Nadu Agricultural University B.Tech Biotechnology
  2009 - 2013

Projects & Funding

Projects & funding information is unavailable.

Publications (13)

• Editing of homologous globin genes by nickase-deficient base editor mitigates large intergenic deletions in HSPCs
  Molecular Therapy - Nucleic Acids 2024 DOI: 10.1016/j.omtn.2024.102347
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• Precise correction of a spectrum of β-thalassemia mutations in coding and non-coding regions by base editors
  Molecular Therapy - Nucleic Acids 2024 DOI: 10.1016/j.omtn.2024.102205
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• Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression
  Molecular Therapy 2024 DOI: 10.1016/j.ymthe.2024.01.023
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• Protocol for arrayed gRNA screening by base editors in mammalian cell lines using lentiviral system
  STAR Protocols 2023 DOI: 10.1016/j.xpro.2023.102668
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• Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2
  Frontiers in Genome Editing 2022 DOI: 10.3389/fgeed.2022.1085111
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• Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin
  eLife 2022 DOI: 10.7554/elife.65421
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• Preferential Expansion of Human CD34+CD133+CD90+ Hematopoietic Stem Cells Enhances Gene-Modified Cell Frequency for Gene Therapy
  Human Gene Therapy 2022 DOI: 10.1089/hum.2021.089
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• Genome Engineering of Hematopoietic Stem Cells Using CRISPR/Cas9 System
  Methods in Molecular Biology 2022 DOI: 10.1007/978-1-0716-1979-7_20
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• CRISPR/Cas based gene editing: marking a new era in medical science
  Molecular Biology Reports 2021 DOI: 10.1007/s11033-021-06479-7
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• Base editing to recapitulate HPFH mutation in the human gamma-globin promoter regions for the induction of fetal hemoglobin
  Cell Symposia: Gene- and Cell-Based Therapies: CRISPR, Stem Cells, and Beyond 2020
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