Souvik Patra

About

My research focuses on understanding how diet–microbiome interactions regulate cancer metabolism, anti-tumor immunity, and therapeutic response. I am particularly interested in pancreatic ductal adenocarcinoma, a metabolically rewired and immunosuppressive cancer with limited response to current immunotherapies. My current work investigates how distinct dietary fiber types remodel the gut microbiome to generate microbial metabolites that alter tumor lipid metabolism, nutrient availability within the tumor microenvironment, and immune cell function. Using preclinical pancreatic cancer models, microbiome profiling, metabolomics, lipidomics, transcriptomics, and flow cytometry-based immune profiling, I aim to identify fiber-driven metabolic pathways that suppress tumor progression and enhance response to immune checkpoint blockade. Ultimately, my goal is to develop mechanistically informed precision nutrition strategies that can be integrated with cancer therapy to improve treatment outcomes.

Employment

• Van Andel Institute Postdoctoral fellow
  2025 - Present

Education

• Texas Tech University Ph.D.
  2021 - 2025
• Vellore Institute of Technology University Master of Science
  2012 - 2017

Projects & Funding

Projects & funding information is unavailable.

Publications (12)

• A high-fat, low-carbohydrate diet can feed intestinal tumours
  Nature 2026 DOI: 10.1038/d41586-026-02039-w
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• Diabetic and overweight cats have altered gut microbial diversity and composition
  The Veterinary Journal 2026 DOI: 10.1016/j.tvjl.2026.106687
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• Maternal Protein Restriction and Branched-Chain Amino Acid Supplementation Differentially Affect Maternal Energy Balance and Impair Offspring Growth
  Nutrients 2026 DOI: 10.3390/nu18020322
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• Discovery of pan-EphB tyrosine kinase inhibitor for metabolic syndrome sparing EphB3 signaling in mice
  Pharmacological Research 2025 DOI: 10.1016/j.phrs.2025.107900
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• Microencapsulated Propionate and Butyrate Improved Energy Balance and Gut Microbiota Composition in Diet-Induced Obese Rats
  Nutrients 2025 DOI: 10.3390/nu17132180
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• Prebiotics pectin and resistant starch‐type 4 stimulate peptide YY and cholecystokinin to promote satiety, and improve gut microbiota composition
  The FASEB Journal 2025 DOI: 10.1096/fj.202403239R
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• Feline Diabetes Is Associated with Deficits in Markers of Insulin Signaling in Peripheral Tissues
  International Journal of Molecular Sciences 2024 DOI: 10.3390/ijms252313195
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• Structure-Based Drug Repurposing Targeting Malonyl-CoA Decarboxylase for Treatment of Obesity
  The Journal of Pharmacology and Experimental Therapeutics 2024 DOI: 10.1124/jpet.282.926640
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• OR12-01-23 Maternal Supplementation of Prebiotic Fiber Improves Energy Balance and Protects Offspring Against Diet-Induced Obesity
  Current Developments in Nutrition 2023 DOI: 10.1016/j.cdnut.2023.100978
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• P31-057-23 Prebiotic Fibers Engage a Microbiota-Endocrine-Neural Axis To Treat Obesity
  Current Developments in Nutrition 2023 DOI: 10.1016/j.cdnut.2023.101622
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