Mahajan Mukesh
University of California San Diego, San Diego Supercomputer Center, Nanyang Technological University, Govind Ballabh Pant Engineering College, Case Western Reserve University
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Protein Structure and Dynamics · Lipid Membrane Structure and Behavior · Chemical Synthesis and Analysis
0000-0002-8153-7613
About
My research interest lies in understanding structure-based functional dynamics of membrane-active proteins and peptides in a native membrane environment (model lipid membranes e.g. lipid nanodiscs, bicelles, and micelles) using advanced solution NMR spectroscopy, small-angle X-ray scattering, All-atom molecular dynamics simulation, and multiple tools of molecular biophysics to answer critical biological questions stemming from protein-protein and protein-lipid interactions.
Employment
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University of California, San Diego Staff Research Associate2023 - Present
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San Diego Supercomputer Center Visiting Researcher2022 - Present
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Case Western Reserve University Research Associate2022 - 2022
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Dana Farber Cancer Institute Research Fellow2019 - 2020
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University of Michigan Research Fellow2017 - 2019
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Case Western Reserve University Post doctoral Scholar2015 - 2016
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Nanyang Technological University Research Associate2013 - 2015
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Beant College of Engineering and Technology Lecturer2008 - 2008
Education
- 2009 - 2014
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Govind Ballabh Pant Engineering College M.Tech2006 - 2008
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Punjab Technical University Bachelor in Pahrmacy2001 - 2005
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Punjab School Board of Technical Education and Industrial Training Diploma in Pharmacy1999 - 2001
Projects & Funding
Projects & funding information is unavailable.
Publications (16)
- Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif Save
- NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission Save
- Directed Evolution Using Stabilized Bacterial Peptide Display Save
- Probing membrane enhanced protein–protein interactions in a minimal redox complex of cytochrome-P450 and P450-reductase Save
- A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs Save
- Cytochrome-P450's Spin State Influences its Binding Affinity to its Redox Partner Save
- NMR structure and localization of a large fragment of the SARS-CoV fusion protein: Implications in viral cell fusion Save
- Kinetic and Structural Characterization of the Effects of Membrane on the Complex of Cytochrome b 5 and Cytochrome c Save
- Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5 Save
- Piscidin-1-analogs with double L- and D-lysine residues exhibited different conformations in lipopolysaccharide but comparable anti-endotoxin activities Save
- Designed multi-stranded heme binding β-sheet peptides in membrane Save
- NMR structures and localization of the potential fusion peptides and the pre-transmembrane region of SARS-CoV: Implications in membrane fusion Save
- Designed Di-Heme binding helical transmembrane protein Save
- Erratum: Designed Di-Heme binding helical transmembrane protein(ChemBioChem (20140) 15 (1257-1262) DOI: 10.1002/cbic.201402142) Save
- Inside Cover: Designed Di-Heme Binding Helical Transmembrane Protein (ChemBioChem 9/2014) Save
- β-hairpin peptides: Heme binding, catalysis, and structure in detergent micelles Save