MB
Mihaly Badonyi
University of Edinburgh, Max Planck Institute of Molecular Cell Biology and Genetics, University of Aberdeen, Scotia Biologics Limited, University of Szeged
Research areas: Biochemistry, Genetics and Molecular Biology · Genetics · Genomics and Rare Diseases · Genetic Associations and Epidemiology · RNA and protein synthesis mechanisms
0000-0002-8305-5618
Employment
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University of Edinburgh Visiting Fellow2025 - Present
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Max Planck Institute of Molecular Cell Biology and Genetics Postdoctoral Fellow2025 - Present
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University of Edinburgh Postdoctoral Researcher2023 - 2025
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Scotia Biologics Limited Senior Research Scientist2016 - 2019
Education
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University of Edinburgh Human Genetics and Molecular Medicine PhD2019 - 2023
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University of Aberdeen Medical Sciences and Bio-Business MSc2014 - 2016
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University of Szeged Bioengineering and Applied Biotechnology BSc2010 - 2014
Projects & Funding
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Protein Structure, Molecular Mechanisms and Human Genetic Disease: Beyond the Loss-of-function Paradigm European Research Council2021 - 2026
Publications (28)
- Pinc: a simple probabilistic AlphaFold interaction score Save
- acmgscaler: an R package and Colab for standardized gene-level variant effect score calibration within the ACMG/AMP framework Save
- Prevalence of loss-of-function, gain-of-function and dominant-negative mechanisms across genetic disease phenotypes Save
- Disease-associated genetic variants can cause mutations in tissue-specific protein isoforms Save
- acmgscaler: An R package and Colab for standardised gene-level variant effect score calibration within the ACMG/AMP framework Save
- Prevalence of loss-of-function, gain-of-function and dominant-negative mechanisms across genetic disease phenotypes Save
- Complementary Roles of Structure and Variant Effect Predictors in RyR1 Clinical Interpretation Save
- Structural extension of the human exocyst is enabled by a minimal interface Save
- Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID Save
- Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID Save
- Proteome-scale prediction of molecular mechanisms underlying dominant genetic diseases Save
- Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus Save
- Hallmarks and evolutionary drivers of cotranslational protein complex assembly Save
- ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma Save
- Interface Gain-of-Function Mutations in TLR7 Cause Systemic and Neuro-inflammatory Disease Save
- Dominant negative effects on H3K27 methylation by Weaver syndrome-associated EZH2 variants Save
- Guidelines for releasing a variant effect predictor Save
- Pervasive ancestry bias in variant effect predictors Save
- Proteome-scale prediction of molecular mechanisms underlying dominant genetic diseases Save
- CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence Save