Mina S. Sedrak, MD, MS, FASCO
University of California, Los Angeles, City Of Hope National Medical Center, University of Pennsylvania, Rush Medical College of Rush University, Hospital of the University of Pennsylvania
Research areas: Medicine · Geriatrics and Gerontology · Frailty in Older Adults · Breast Cancer Treatment Studies · Cancer survivorship and care
0000-0002-8379-391X
About
Dr. Sedrak is an Associate Professor of Medicine and Director of the UCLA Center for Cancer and Aging. He also co-leads the Cancer Control and Survivorship Research Program at the UCLA Jonsson Comprehensive Cancer Center.
Dr. Sedrak is a medical oncologist specializing in the care of older adults with breast cancer. His research program is devoted to understanding the dynamic interplay between cancer and aging. His work seeks to develop interventions that target fundamental processes of aging to prevent or reverse the long-term adverse health consequences of cancer treatment, such as accelerated aging in skeletal muscle, loss of independence, and frailty. By integrating laboratory discovery with clinical investigation, his translational research aims to inform novel biology-driven strategies to mitigate treatment-related accelerated aging and improve long-term outcomes.
He has designed and led therapeutic trials for older adults with breast cancer, systematically evaluated barriers to clinical trial participation, and collaborated with regulatory bodies, policymakers, and industry sponsors to expand inclusion of older and frail adults in research. These efforts have addressed critical gaps in evidence for a rapidly growing and high-risk population, and his work has informed evidence-based guidelines that are shaping standards of care for older adults with cancer. He received the Paul B. Beeson Emerging Leaders Career Development Award from the National Institute on Aging and the Susan G. Komen Rising Star Researcher Award.
Beyond his scientific accomplishments, Dr. Sedrak is committed to mentoring the next generation of physician-scientists and leaders in cancer and aging research. As Co-Chair of the Alliance Cancer in the Older Adult Committee, Co-Chair of the Analytics Core in the Cancer and Aging Research Group, and Chair of the ASCO Clinical Research Committee, he has fostered cross-disciplinary collaboration and championed support for trainees as well as early- and mid-career faculty dedicated to improving the care of cancer patients and survivors.
Employment
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University of California, Los Angeles Associate Professor of Medicine with Tenure2023 - Present
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City of Hope Associate Professor2023 - 2023
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City of Hope Assistant Professor2016 - 2023
- 2013 - 2016
- 2011 - 2013
- 2010 - 2011
Education
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University of Pennsylvania MS (Health Policy Research)2014 - 2015
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Rush Medical College of Rush University MD (Medicine)2006 - 2010
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University of Chicago BA (Biologic Sciences)2002 - 2006
Projects & Funding
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Enhancing Skeletal Muscle Recovery and Mitochondrial Function in Older Cancer Survivors National Institute of Arthritis and Musculoskeletal and Skin Diseases2026 - 2029
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Targeting Senescence to Mitigate Chemotherapy-induced Functional Decline National Cancer Institute2023 - 2028
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Using Senolytics to Improve Physical Function in Older Breast Cancer Survivors National Cancer Institute2022 - 2024
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Targeting Senescence to Improve Frailty in Older Cancer Survivors National Institute on Aging2022 - 2023
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Improving Clinical Trial Participation of Older Adults with Cancer National Institute on Aging2019 - 2022
Publications (123)
- Efficacy and toxicity of antibody-drug conjugates in older adults with breast cancer: A systematic review and meta-analysis Save
- Putting the Patient at the Center of Patient-Centered Care Save
- Results From a Phase II Single-Arm Trial Evaluating the Safety and Efficacy of Anhydrous Enol-Oxaloacetate on Improving Cognitive Complaints in Breast Cancer Survivors Save
- p16INK4a and DNA methylation clocks in women treated with chemotherapy for early breast cancer Save
- Patient-reported outcomes in clinical trials leading to breast cancer drug approvals: are we making them count? Save
- “Protected time” for clinical investigators in medical oncology: The persistent gap between expectation and reality Save
- Personalizing cancer care for older adults Save
- A phase II randomized placebo-controlled study of fisetin to improve physical function in breast cancer survivors: the TROFFi study rationale and trial design Save
- Age and Sex in Breast Cancer: Moving Beyond a One-Size-Fits-All Approach Save
- Alterations in Brain White Matter Tractography in Older Long-Term Breast Cancer Survivors Treated with Chemotherapy Save
- Diet, nutrition, and hormone therapy for prostate cancer: a systematic review with implications for future interventions Save
- Epigenetic age acceleration measures and chemotoxicity in older adults with early breast cancer Save
- Impact of Screening Mammography on Breast Cancer Outcomes in Women Aged 80 Years and Over Save
- Socioeconomic disparities in long-term heart failure risk of trastuzumab with or without anthracyclines in early-stage breast cancer: a SEER-Medicare database analysis Save
- ASCO State of Cancer Care in America Special Report 2025: Access to Cancer Clinical Trials in the United States Save
- ASO Visual Abstract: Impact of Screening Mammography on Breast Cancer Outcomes in Women Aged 80 Years and Over Save
- Association between frailty and clinical outcomes in older adults with early breast cancer: Results from the Hurria older patients (HOPE) study. Save
- Frailty: Can a Biological Aging Marker Enhance Precision Risk Assessment of Cancer Therapy Cardiotoxicity? Save
- Geriatric Assessment-driven INterventions among Hospitalized older adults with cancer (GAIN-HOSP), a prospective pilot study Save
- Gerotherapeutics: aging mechanism–based pharmaceutical and behavioral interventions to reduce cancer racial and ethnic disparities Save