Shaji R Velayudhan

About

I completed my Masters in Science (M Sc) in Biotechnology from Goa University, Goa, and, subsequently, joined for PhD at Christian Medical College, Vellore. After the completion of the PhD, I carried out my postdoctoral fellowship at St Jude Children's Research Hospital, Memphis and the University of Chicago, Chicago.

My area of research interest is disease modelling of haematological diseases.

Employment

• Christian Medical College and Centre for Stem Cell Research (A Unit of inStem) Professor and Adjunct Scientist
  2001 - Present

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (105)

• Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A.
  The New England journal of medicine 2025 DOI: 10.1056/nejmc2502741
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• UTF1 Expression is Important for the Generation and Maintenance of Human iPSCs.
  Stem cell reviews and reports 2025 DOI: 10.1007/s12015-024-10836-x
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• Editing of homologous globin genes by nickase-deficient base editor mitigates large intergenic deletions in HSPCs.
  Molecular therapy. Nucleic acids 2024 DOI: 10.1016/j.omtn.2024.102347
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• Precise correction of a spectrum of β-thalassemia mutations in coding and non-coding regions by base editors.
  Molecular therapy. Nucleic acids 2024 DOI: 10.1016/j.omtn.2024.102205
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• Inhibition of NRF2 signaling overcomes acquired resistance to arsenic trioxide in FLT3-mutated Acute Myeloid Leukemia.
  Annals of hematology 2024 DOI: 10.1007/s00277-024-05742-8
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• Efficient deletion of microRNAs using CRISPR/Cas9 with dual guide RNAs.
  Frontiers in molecular biosciences 2024 DOI: 10.3389/fmolb.2023.1295507
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• Immortalised chronic myeloid leukemia (CML) derived mesenchymal stromal cells (MSCs) line retains the immunomodulatory and chemoprotective properties of CML patient-derived MSCs.
  Cellular signalling 2024 DOI: 10.1016/j.cellsig.2024.111067
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• Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression.
  Molecular therapy : the journal of the American Society of Gene Therapy 2024 DOI: 10.1016/j.ymthe.2024.01.023
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• Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression.
  Scientific reports 2023 DOI: 10.1038/s41598-023-42174-2
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• Establishment and characterization of CSCRi006-A: an induced pluripotent stem cell line generated from a patient with Diamond-Blackfan Anemia (DBA) carrying ribosomal protein S19 (RPS19) mutation
  Human Cell 2023 DOI: 10.1007/s13577-023-00946-y
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