Manvendra Singh

About

Transposable or Transposed elements (TrEs) are a productive source of biochemically active non-coding or occasionally coding elements that are tightly regulated in a cell-type specific manner. Many recent studies strengthen the hypothesis that few of these elements are co-opted for the regulation of host genes. We focus on one particular large family of human ERVs, which we find as a key regulatory player in the human pluripotent stem cells. I show that its co-option has potentially led the evolution and development of human-specific embryogenesis including the pluripotency. We updated transcriptomic encyclopedia of early human embryogenesis with their transcriptional flags. We re-define the progression of human embryogenesis at single-cell resolution with their markers. In conjecture with previous definitions, we characterize an unattended cell population in human preimplantation embryos that did or did not commit to any of the known lineages in order to form the stable blastocyst. Human transposcriptomics illustrate the contrasting pattern of transposon families during the progression of preimplantation embryogenesis. Their cross-talk with host factors could have driven the commitment of host cells to the particular lineages, leading to rapid turnover, compared with another species.

Employment

• CNRS Chaire de Professor Junior
  2027 - Present
• Institut Necker Enfants Malades Professor
  2026 - Present
• CIMH Senior Scientist
  2025 - Present
• Max Planck Institute for Multidisciplinary Sciences Senior Scientist
  2022 - 2025
• Cornell University Post-doctoral Associate
  2019 - 2022
• Max Delbrück Centrum für Molekulare Medizin Berlin Buch Scientist
  2017 - 2019
• University of Bath Research scholar
  2015 - 2015
• Max Delbrück Centrum für Molekulare Medizin Berlin Buch PhD Student
  2012 - 2017
• Centre for Cellular and Molecular Biology CSIR Junior Research Fellow
  2008 - 2012

Education

• Freie Universität Berlin Dr. rer. nat.
  2015 - 2018
• Max Delbrück Center for Molecular Medicine PhD
  2012 - Present
• Jawaharlal Nehru University M.Sc
  2007 - 2008
• Bundelkhand University Masters of Science
  2006 - 2008

Projects & Funding

Projects & funding information is unavailable.

Publications (40)

• Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk
  2026 DOI: 10.64898/2026.01.20.700661
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• Erythropoietin reshapes the adult hippocampal chromatin landscape to promote neurogenesis
  2025 DOI: 10.1101/2025.10.13.682070
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• Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors
  2025 DOI: 10.1101/2025.09.11.675614
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• Transposable elements may enhance antiviral resistance in HIV-1 elite controllers
  2023 DOI: 10.1101/2023.12.11.571123
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• Erythropoietin re-wires cognition-associated transcriptional networks
  Nature Communications 2023 DOI: 10.1038/s41467-023-40332-8
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• Maternal-derived galectin-1 shapes the placenta niche through Sda terminal glycosylation: Implication for preeclampsia
  PNAS Nexus 2023 DOI: 10.1093/pnasnexus/pgad247
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• Staring at the onco-exaptation: the two-faced medley of an ancient retrovirus, HERVH
  Journal of Clinical Investigation 2023 DOI: 10.1172/JCI172278
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• PNMA2 forms non-enveloped virus-like capsids that trigger paraneoplastic neurological syndrome
  2023 DOI: 10.1101/2023.02.09.527862
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• Transcriptional networks predating cognition-associated pyramidal lineages are restructured by erythropoietin
  2023 DOI: 10.1101/2023.02.04.527116
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• A Novel Gene Controls a New Structure: PiggyBac Transposable Element-Derived 1, Unique to Mammals, Controls Mammal-Specific Neuronal Paraspeckles
  Molecular Biology and Evolution 2022 DOI: 10.1093/molbev/msac175
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