Gautam Srivastava

About

A self-motivated scientist with expertise in Protein chemistry and Structural biology with special emphasis on biomolecular interaction at atomic level, that includes fast exchange weak-binding and strong binding protein complexes. I have broad knowledge as well as experience in the field of Ser/Thr Phosphoprotein Phosphatase (PPPs) family of proteins involved in signal transduction, Receptor Binding Domain of HIV1-gp120 and optical pure molecules for synthesis of pharmaceutically important drugs. Excellent interpersonal, collaborative, communication, presentation, reviewing and writing skills.

Employment

• UT Health San Antonio Cancer Center Senior Research Scientist
  2023 - Present
• UConn Health Postdoctoral Fellow
  2020 - 2023
• University of Arizona Postdoctoral Fellow
  2018 - 2020
• Weizmann Institute of Science Postdoctoral Fellow
  2014 - 2018
• Institute of Microbial Technology Research Associate
  2013 - 2014
• Ind-Swift Laboratories Ltd Quality Control Chemist
  2004 - 2006

Education

• CSIR - Institute of Microbial Technology Doctor of Philosophy
  2006 - 2013
• Goa University Master of Science
  2001 - 2003
• Veer Bahadur Singh Purvanchal University Bachelor of Science
  1996 - 1999

Projects & Funding

Projects & funding information is unavailable.

Publications (12)

• The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to prime metal exchange
  Journal of Biological Chemistry 2024 DOI: 10.1016/j.jbc.2023.105515
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• Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein–protein interaction
  Nature Communications 2023 DOI: 10.1038/s41467-023-37372-5
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• The ribosomal RNA processing 1B:protein phosphatase 1 holoenzyme reveals non-canonical PP1 interaction motifs
  Cell Reports 2022 DOI: 10.1016/j.celrep.2022.111726
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• Defining specific residue-to-residue interactions between the gp120 bridging sheet and the N-terminal segment of CCR5: applications of transferred NOE NMR.
  The FEBS journal 2018 DOI: 10.1111/febs.14673
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• The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5.
  The FEBS journal 2018 DOI: 10.1111/febs.14460
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• Detection of intermolecular transferred-NOE interactions in small and medium size protein complexes: RANTES complexed with a CCR5 N-terminal peptide.
  The FEBS journal 2017 DOI: 10.1111/febs.14000
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• Detection of intermolecular transferred NOEs in large protein complexes using asymmetric deuteration: HIV-1 gp120 in complex with a CCR5 peptide.
  The FEBS journal 2016 DOI: 10.1111/febs.13916
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• Detection of intermolecular NOE interactions in large protein complexes.
  Progress in nuclear magnetic resonance spectroscopy 2016 DOI: 10.1016/j.pnmrs.2016.08.002
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• Novel immunosuppressive agent caerulomycin A exerts its effect by depleting cellular iron content.
  British journal of pharmacology 2015 DOI: 10.1111/bph.13051
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• A highly efficient designer cell for enantioselective reduction of ketones
  Catalysis Science & Technology 2015 DOI: 10.1039/c4cy01017e
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